Disease relevance of PER2

• Animals responded to the simulated lactational Ca loss (period 2) by increasing true intestinal absorption of Ca and bone resorption and by reducing Ca accretion by bone [1].

High impact information on PER2

• Per1 and Per2 peaked during the day, whereas Cry1 and Cry2 peaked early in the night [2].
• In sham-treated animals, PT expression of Per1, Per2, and Rev-erbalpha showed pronounced temporal variation despite the absence of melatonin, with peak times occurring earlier than predicted under LP [3].
• In experimental lungs, inspired O2 concentration (FIO2) was 28.2% in periods 1 and 3 and 4.2% in period 2 [4].
• The 24-h pattern in plasma cortisol matched the observed phasing of Per2 expression, suggesting that it may act as an endocrine entraining factor [5].
• In Periods 1 (late gestation) and 2 (early lactation), ewes (Period 1) and ewes with lambs (Period 2) were individually penned, fed .45 kg of barley x ewe(-1) x d(-1) and allowed ad libitum access to chopped alfalfa [6].

Biological context of PER2

• Slaughter group ewes were also subjected to 8-h serial blood sampling at 98 d (period 1) and 123 d (period 2) of gestation [7].
• Both treatments produced hypercalciuria during both periods, and the lowest cation-anion balance increased true intestinal absorption of Ca and reduced bone accretion during period 2 [1].
• Twelve crossbred wethers were used as eucalcemic control (period 1); then Ca loss during lactation was simulated by continuous infusion of ethylene glycol tetraacetate (period 2) [1].
• 2. Fasting heat production (FHP) of four lambs from each treatment was determined at the end of period 2 [8].
• 4. Within groups of lambs of similar weight at the end of period 2, body composition was, in general, similar, but FHP was greater in lambs that had been on higher planes of nutrition during period 2 [8].

Anatomical context of PER2

• 5. Within groups of lambs of similar weight, lambs that were fed at higher planes of nutrition during period 2 had greater weights or proportions of liver, small intestine, large intestine and stomach [8].

Associations of PER2 with chemical compounds

• During four 8-d conditioning periods, the amounts of propionate delivered ranged from .7 to 1.4% of the daily DE intake (Period 1) or were fixed at .7% (Period 2) and 1% of the daily DE intake (Periods 3 and 4) [9].

References