Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

ADRB1 - adrenoceptor beta 1

Ovis aries

Liu, J. et al., Tseng, Y.T. et al., Bernstein, D. et al., Tseng, Y.T. et al., Padbury, J.F. et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on ADRB1

We now report data on ovine beta 1AR gene expression obtained by transient transfection [1].
We cloned and sequenced the ovine beta 1 adrenergic receptor (beta 1AR) gene and promoter region [2].
Functional analysis of the 5' flanking sequence in the ovine beta 1-adrenergic receptor gene [1].
We previously cloned the ovine beta 1AR gene and mapped the transcription start sites [1].
Ontogeny and effects of thyroid hormone on beta1-adrenergic receptor mRNA expression in ovine fetal kidney cortex [3].

Biological context of ADRB1

CONCLUSION: The data suggest that thyroid hormone may be involved in modulating ovine fetal renocortical beta1R gene expression during development [3].
An inverted cAMP response element mediates the cAMP induction of the ovine beta 1-adrenergic receptor gene [4].
RESULTS: Renocortical beta1R mRNA expression increased significantly between 100 and 140 days' gestational age (dGA), while TX attenuated this increase (P <.01) [3].
We speculate that the increased beta1R mRNA expression in renal cortical cells as development progresses may mediate the increases in renin gene response to beta-adrenergic stimulation in late gestation [3].

Anatomical context of ADRB1

METHODS: Renocortical tissue was obtained from naive, TX, and sham-operated fetuses to determine beta1R mRNA levels [3].

Analytical, diagnostic and therapeutic context of ADRB1

Steady-state levels of beta-receptor mRNA were determined by Northern blot analysis using a beta 1-adrenergic receptor cDNA probe [5].

References

Functional analysis of the 5' flanking sequence in the ovine beta 1-adrenergic receptor gene. Tseng, Y.T., Waschek, J.A., Padbury, J.F. Biochem. Biophys. Res. Commun. (1995) [Pubmed]
Transcription initiation is localized to a TATAless region in the ovine beta 1 adrenergic receptor gene. Padbury, J.F., Tseng, Y.T., Waschek, J.A. Biochem. Biophys. Res. Commun. (1995) [Pubmed]
Ontogeny and effects of thyroid hormone on beta1-adrenergic receptor mRNA expression in ovine fetal kidney cortex. Liu, J., Chen, K., Valego, N.K., Carey, L.C., Rose, J.C. J. Soc. Gynecol. Investig. (2005) [Pubmed]
An inverted cAMP response element mediates the cAMP induction of the ovine beta 1-adrenergic receptor gene. Tseng, Y.T., Stabila, J., McGonnigal, B., Nguyen, T.T., Padbury, J.F. Biochem. Mol. Biol. Int. (1998) [Pubmed]
Transcriptional regulation of left ventricular beta-adrenergic receptors during chronic hypoxia. Bernstein, D., Doshi, R., Huang, S., Strandness, E., Jasper, J.R. Circ. Res. (1992) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.