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Gene Review

CRP  -  C-reactive protein, pentraxin-related

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High impact information on CRP

  • Three possible promoters and a CRP binding site were identified by concensus criteria [1].
  • A concentration of CRP similar to that detected in patients with cardiovascular risk (10 microg/ml) failed to modify the generation of superoxide anion stimulated by TNF-alpha [2].
  • Western blot experiments showed that TNF-alpha decreased the expression of the eNOS protein, which was partially protected by treatment with 10 microg/ml CRP [2].
  • Bovine CRP was composed of a single type of non-glycosylated subunit whilst bovine SAP contained two major types of glycosylated subunits and a minor polypeptide, the glycosylation of which was not determined [3].
  • Latex agglutination test: a simple, rapid and practical method for bovine serum CRP determination [4].

Associations of CRP with chemical compounds

  • 1. A new purification procedure was started with salting-out fractionation of serum proteins at 45-75% saturated ammonium sulfate concentration, followed by HE agarose affinity chromatography by which calcium-dependently bound CRP and SAP were purely eluted with EDTA-containing buffer [5].

Other interactions of CRP


Analytical, diagnostic and therapeutic context of CRP

  • Although the mixture of these two pentraxins was not resolved by gel filtration chromatography, they were separated by solid phase absorption of the CRP with immobilized rabbit anti-human CRP antibodies [3].
  • Confocal microscopy experiments showed a weak expression of the CD32 receptor in control BAEC that was slightly increased by 10 microg/ml CRP [2].
  • 2. Pure CRP and SAP were finally separated by DEAE-5PW HPLC [5].
  • The critical roughage part (CRP) of 2 diet types was determined in a cross-over design with 6 double-muscled and 6 normally conformed Belgian Blue bulls fitted with rumen cannulae [6].


  1. Nucleotide sequence of the promoter and amino-terminal coding region of the glutamate dehydrogenase structural gene of Escherichia coli. Valle, F., Sanvicente, E., Seeburg, P., Covarrubias, A., Rodriguez, R.L., Bolivar, F. Gene (1983) [Pubmed]
  2. Effect of C-reactive protein on Fcgamma receptor II in cultured bovine endothelial cells. Escribano-Burgos, M., López-Farré, A., del Mar González, M., Macaya, C., García-Méndez, A., Mateos-Cáceres, P.J., Alonso-Orgaz, S., Carrasco, C., Rico, L.A., Porres Cubero, J.C. Clin. Sci. (2005) [Pubmed]
  3. Identification and isolation of two pentraxins from bovine serum. Maudsley, S., Rowe, I.F., de Beer, F.C., Munn, E.A., Herbert, J., Feinstein, A., Pepys, M.B. Clin. Exp. Immunol. (1987) [Pubmed]
  4. Latex agglutination test: a simple, rapid and practical method for bovine serum CRP determination. Sarikaputi, M., Morimatsu, M., Yamamoto, S., Syuto, B., Saito, M., Naiki, M. Jpn. J. Vet. Res. (1992) [Pubmed]
  5. A new purification procedure for bovine C-reactive protein and serum amyloid P component. Sarikaputi, M., Morimatsu, M., Syuto, B., Saito, M., Naiki, M. Int. J. Biochem. (1991) [Pubmed]
  6. Decreasing the roughage:concentrate ratio of a diet to determine the critical roughage part for beef cattle. De Campeneere, S., Fiems, L.O., De Boever, J.L., Vanacker, J.M., De Brabander, D.L. Archiv für Tierernährung. (2002) [Pubmed]
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