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MeSH Review

Dietary Fiber

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Disease relevance of Dietary Fiber


Psychiatry related information on Dietary Fiber


High impact information on Dietary Fiber

  • Human colonic bacteria ferment RS and nonstarch polysaccharides (NSP; major components of dietary fiber) to short-chain fatty acids (SCFA), mainly acetate, propionate, and butyrate [9].
  • However, it is not known whether oat-bran diets lower serum cholesterol levels by replacing fatty foods in the diet or by a direct effect of the dietary fiber contained in oat bran [10].
  • We evaluated in detail usual intake of vegetables and fruits (each measured as the total reported grams consumed for all queried vegetables and fruit), vitamins C and E, folic acid, individual carotenoids, and dietary fiber with its components [11].
  • This inverse association was found to be independent of vitamin C,alpha-tocopherol, folic acid, dietary fiber, and alpha-carotene.Adjusting for beta-carotene or lutein + zeaxanthin somewhat attenuated the inverse association with vegetable intake [11].
  • Effects of dietary fiber on N-nitrosomethylurea-induced mammary tumors and on plasma estrogen levels in rats [12].

Chemical compound and disease context of Dietary Fiber


Biological context of Dietary Fiber


Anatomical context of Dietary Fiber


Associations of Dietary Fiber with chemical compounds

  • BACKGROUND: Epidemiologic evidence of associations between the high intake of fat and low intake of dietary fiber, beta carotene, and other dietary constituents and the risk of colorectal neoplasia has been inconsistent and has not provided a sufficient basis for recommendations concerning the dietary prevention of large-bowel cancer in humans [1].
  • The percent of the carcinogen 1,2-dimethylhydrazine (DMH) bound to a variety of fibers, such as wheat bran, corn bran, citrus pulp, citrus pectin, and alfalfa, was examined at pH values ranging from 1 to 12 [28].
  • Effect of dietary fiber on azoxymethane-induced intestinal carcinogenesis in rats [29].
  • The interaction of dietary fibers and cholesterol upon the plasma lipids and lipoproteins, sterol balance, and bowel function in human subjects [30].
  • 0. Results from this experiment showed that the affinity to various types of dietary fibers for the colon carcinogen DMH was differentially affected by pH [28].

Gene context of Dietary Fiber

  • In vivo, increasing dietary fiber increased colonic, but not proximal, ileal hsp25 while having no effect on hsp72 or hsc73 expression [31].
  • Sodium butyrate (NaB), a short chain fatty acid, is a HDAC inhibitor and is produced in the colonic lumen as a consequence of microbial degradation of dietary fibers [32].
  • Min mice were fed the following high-fat (40% of energy) diets for 5-6 weeks; a high-beef diet and a casein-based diet without added fiber or casein-based diet with 10% (w/w) oat, rye or wheat bran, or 2.5% (w/w) inulin [33].
  • However, butyrate, an important luminal component produced from fermentation of dietary fibers, is an efficient inducer of GSTs and especially of GSTM2 [34].
  • Consumption of saturated fat was found to decrease, and intake of omega-3 polyunsaturated fatty acids and of dietary fiber was found to increase circulating IGFBP-3 concentrations [35].

Analytical, diagnostic and therapeutic context of Dietary Fiber


  1. Randomized trial of intake of fat, fiber, and beta carotene to prevent colorectal adenomas. MacLennan, R., Macrae, F., Bain, C., Battistutta, D., Chapuis, P., Gratten, H., Lambert, J., Newland, R.C., Ngu, M., Russell, A., Ward, M., Wahlqvist, M.L. J. Natl. Cancer Inst. (1995) [Pubmed]
  2. AGA technical review: impact of dietary fiber on colon cancer occurrence. Kim, Y.I. Gastroenterology (2000) [Pubmed]
  3. Butyric acid induces apoptosis by up-regulating Bax expression via stimulation of the c-Jun N-terminal kinase/activation protein-1 pathway in human colon cancer cells. Mandal, M., Olson, D.J., Sharma, T., Vadlamudi, R.K., Kumar, R. Gastroenterology (2001) [Pubmed]
  4. Dietary impact on biliary lipids and gallstones. Hayes, K.C., Livingston, A., Trautwein, E.A. Annu. Rev. Nutr. (1992) [Pubmed]
  5. Secoisolariciresinol dehydrogenase purification, cloning, and functional expression. Implications for human health protection. Xia, Z.Q., Costa, M.A., Pelissier, H.C., Davin, L.B., Lewis, N.G. J. Biol. Chem. (2001) [Pubmed]
  6. Diet, physical activity, and gallstones--a population-based, case-control study in southern Italy. Misciagna, G., Centonze, S., Leoci, C., Guerra, V., Cisternino, A.M., Ceo, R., Trevisan, M. Am. J. Clin. Nutr. (1999) [Pubmed]
  7. Homocysteine, cardiovascular disease risk factors, and habitual diet in the French Supplementation with Antioxidant Vitamins and Minerals Study. Mennen, L.I., de Courcy, G.P., Guilland, J.C., Ducros, V., Bertrais, S., Nicolas, J.P., Maurel, M., Zarebska, M., Favier, A., Franchisseur, C., Hercberg, S., Galan, P. Am. J. Clin. Nutr. (2002) [Pubmed]
  8. Feeding behavior changes of cattle during introduction of monensin with roughage or concentrate diets. Baile, C.A., McLaughlin, C.L., Potter, E.L., Chalupa, W. J. Anim. Sci. (1979) [Pubmed]
  9. Short-chain fatty acids and human colonic function: roles of resistant starch and nonstarch polysaccharides. Topping, D.L., Clifton, P.M. Physiol. Rev. (2001) [Pubmed]
  10. Comparison of the effects of oat bran and low-fiber wheat on serum lipoprotein levels and blood pressure. Swain, J.F., Rouse, I.L., Curley, C.B., Sacks, F.M. N. Engl. J. Med. (1990) [Pubmed]
  11. Premenopausal breast cancer risk and intake of vegetables, fruits, and related nutrients. Freudenheim, J.L., Marshall, J.R., Vena, J.E., Laughlin, R., Brasure, J.R., Swanson, M.K., Nemoto, T., Graham, S. J. Natl. Cancer Inst. (1996) [Pubmed]
  12. Effects of dietary fiber on N-nitrosomethylurea-induced mammary tumors and on plasma estrogen levels in rats. Arts, C.J., van den Berg, H., Thijssen, J.H. J. Natl. Cancer Inst. (1991) [Pubmed]
  13. The need for comprehensive diet studies to assess the relation of lipids to cancer. Sorenson, A.W., Street, J.C. Cancer Res. (1981) [Pubmed]
  14. Effect of dietary fiber on the induction of colorectal tumors and fecal beta-glucuronidase activity in the rat. Bauer, H.G., Asp, N.G., Oste, R., Dahlqvist, A., Fredlund, P.E. Cancer Res. (1979) [Pubmed]
  15. Interactive effects of dietary wheat bran and lard on N-methyl-N'-nitro-N-nitrosoguanidine-induced colon carcinogenesis in rats. Sinkeldam, E.J., Kuper, C.F., Bosland, M.C., Hollanders, V.M., Vedder, D.M. Cancer Res. (1990) [Pubmed]
  16. Dietary risk factors for hyperoxaluria in calcium oxalate stone formers. Siener, R., Ebert, D., Nicolay, C., Hesse, A. Kidney Int. (2003) [Pubmed]
  17. Dietary fiber stabilizes blood glucose and insulin levels and reduces physical activity in sows (Sus scrofa). de Leeuw, J.A., Jongbloed, A.W., Verstegen, M.W. J. Nutr. (2004) [Pubmed]
  18. Modulation of colonic epithelial cell proliferation, histone acetylation, and luminal short chain fatty acids by variation of dietary fiber (wheat bran) in rats. Boffa, L.C., Lupton, J.R., Mariani, M.R., Ceppi, M., Newmark, H.L., Scalmati, A., Lipkin, M. Cancer Res. (1992) [Pubmed]
  19. Effect of structured dietary fiber on bioavailability of amoxicillin. Lutz, M., Espinoza, J., Arancibia, A., Araya, M., Pacheco, I., Brunser, O. Clin. Pharmacol. Ther. (1987) [Pubmed]
  20. Long-term effects of dietary fiber on glucose tolerance and gastric emptying in noninsulin-dependent diabetic patients. Ray, T.K., Mansell, K.M., Knight, L.C., Malmud, L.S., Owen, O.E., Boden, G. Am. J. Clin. Nutr. (1983) [Pubmed]
  21. Regulation of apolipoprotein B-containing lipoproteins by dietary soluble fiber in guinea pigs. Fernandez, M.L., Vergara-Jimenez, M., Conde, K., Behr, T., Abdel-Fattah, G. Am. J. Clin. Nutr. (1997) [Pubmed]
  22. Gender differences in response to dietary soluble fiber in guinea pigs: effects of pectin, guar gum, and psyllium. Fernandez, M.L., Vergara-Jimenez, M., Romero, A.L., Erickson, S.K., McNamara, D.J. J. Lipid Res. (1995) [Pubmed]
  23. The effect of meat protein and dietary fiber on colonic function and metabolism. II. Bacterial metabolites in feces and urine. Cummings, J.H., Hill, M.J., Bone, E.S., Branch, W.J., Jenkins, D.J. Am. J. Clin. Nutr. (1979) [Pubmed]
  24. Mineral contents of brans passed through the human GI tract. Dintzis, F.R., Watson, P.R., Sandstead, H.H. Am. J. Clin. Nutr. (1985) [Pubmed]
  25. The lignin fraction of plant cell walls. Hartley, R.D. Am. J. Clin. Nutr. (1978) [Pubmed]
  26. Apparent nutrient absorption and upper gastrointestinal transit with fiber-containing enteral feedings. Shinnick, F.L., Hess, R.L., Fischer, M.H., Marlett, J. Am. J. Clin. Nutr. (1989) [Pubmed]
  27. Bcl-2 deregulation leads to inhibition of sodium butyrate-induced apoptosis in human colorectal carcinoma cells. Mandal, M., Wu, X., Kumar, R. Carcinogenesis (1997) [Pubmed]
  28. Carcinogen binding to various types of dietary fiber. Smith-Barbaro, P., Hanson, D., Reddy, B.S. J. Natl. Cancer Inst. (1981) [Pubmed]
  29. Effect of dietary fiber on azoxymethane-induced intestinal carcinogenesis in rats. Nigro, N.D., Bull, A.W., Klopfer, B.A., Pak, M.S., Campbell, R.L. J. Natl. Cancer Inst. (1979) [Pubmed]
  30. The interaction of dietary fibers and cholesterol upon the plasma lipids and lipoproteins, sterol balance, and bowel function in human subjects. Raymond, T.L., Connor, W.E., Lin, D.S., Warner, S., Fry, M.M., Connor, S.L. J. Clin. Invest. (1977) [Pubmed]
  31. Short-chain fatty acids induce intestinal epithelial heat shock protein 25 expression in rats and IEC 18 cells. Ren, H., Musch, M.W., Kojima, K., Boone, D., Ma, A., Chang, E.B. Gastroenterology (2001) [Pubmed]
  32. Expression profiling of sodium butyrate (NaB)-treated cells: identification of regulation of genes related to cytokine signaling and cancer metastasis by NaB. Joseph, J., Mudduluru, G., Antony, S., Vashistha, S., Ajitkumar, P., Somasundaram, K. Oncogene (2004) [Pubmed]
  33. Beef induces and rye bran prevents the formation of intestinal polyps in Apc(Min) mice: relation to beta-catenin and PKC isozymes. Mutanen, M., Pajari, A.M., Oikarinen, S.I. Carcinogenesis (2000) [Pubmed]
  34. Expression of glutathione S-transferases (GSTs) in human colon cells and inducibility of GSTM2 by butyrate. Ebert, M.N., Klinder, A., Peters, W.H., Schäferhenrich, A., Sendt, W., Scheele, J., Pool-Zobel, B.L. Carcinogenesis (2003) [Pubmed]
  35. Determinants of circulating insulin-like growth factor I and insulin-like growth factor binding protein 3 concentrations in a cohort of Singapore men and women. Probst-Hensch, N.M., Wang, H., Goh, V.H., Seow, A., Lee, H.P., Yu, M.C. Cancer Epidemiol. Biomarkers Prev. (2003) [Pubmed]
  36. High-fiber diets in the treatment of diabetes mellitus. Miranda, P.M., Horwitz, D.L. Ann. Intern. Med. (1978) [Pubmed]
  37. Cholesterol-lowering effects of dietary fiber: a meta-analysis. Brown, L., Rosner, B., Willett, W.W., Sacks, F.M. Am. J. Clin. Nutr. (1999) [Pubmed]
  38. Effect of brown rice and soybean dietary fiber on the control of glucose and lipid metabolism in diabetic rats. Madar, Z. Am. J. Clin. Nutr. (1983) [Pubmed]
  39. Supplementation with gum arabic fiber increases fecal nitrogen excretion and lowers serum urea nitrogen concentration in chronic renal failure patients consuming a low-protein diet. Bliss, D.Z., Stein, T.P., Schleifer, C.R., Settle, R.G. Am. J. Clin. Nutr. (1996) [Pubmed]
  40. Fiber intake, serum cholesterol levels, and cardiovascular disease in European individuals with type 1 diabetes. EURODIAB IDDM Complications Study Group. Toeller, M., Buyken, A.E., Heitkamp, G., de Pergola, G., Giorgino, F., Fuller, J.H. Diabetes Care (1999) [Pubmed]
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