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Gene Review

LOC445737  -  cionin

Ciona intestinalis

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Disease relevance of LOC445737

  • Sequence-specific immunochemical analysis showed that the cionin gene is expressed also at peptide level in both the gut and the neural ganglion [1].

High impact information on LOC445737


Anatomical context of LOC445737

  • The sulfated peptides induced concentration-dependent contractions of isolated strips of gallbladder with equal efficacy and similar potencies [ED50: 42 (cionin), 23 (CCK-8-s), and 74 nM (gastrin-17-s)], significantly different from the nonsulfated forms [ED50: 1.7 (CCK-8-ns) and 1.9 microM (gastrin-17-ns)] [5].

Associations of LOC445737 with chemical compounds


Analytical, diagnostic and therapeutic context of LOC445737


  1. cDNA deduced procionin. Structure and expression in protochordates resemble that of procholecystokinin in mammals. Monstein, H.J., Thorup, J.U., Folkesson, R., Johnsen, A.H., Rehfeld, J.F. FEBS Lett. (1993) [Pubmed]
  2. Cionin: a disulfotyrosyl hybrid of cholecystokinin and gastrin from the neural ganglion of the protochordate Ciona intestinalis. Johnsen, A.H., Rehfeld, J.F. J. Biol. Chem. (1990) [Pubmed]
  3. Genomic structure of the gene encoding cionin--a cholecystokinin/gastrin like peptide. Monstein, H.J. Neuroreport (1995) [Pubmed]
  4. Neuroendocrinology of protochordates: insights from Ciona genomics. Sherwood, N.M., Tello, J.A., Roch, G.J. Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. (2006) [Pubmed]
  5. Stimulation of rainbow trout gallbladder contraction by cionin, an ancestral member of the CCK/gastrin family. Schjoldager, B., Jørgensen, J.C., Johnsen, A.H. Gen. Comp. Endocrinol. (1995) [Pubmed]
  6. Molecular cloning of a putative Ciona intestinalis cionin receptor, a new member of the CCK/gastrin receptor family. Nilsson, I.B., Svensson, S.P., Monstein, H.J. Gene (2003) [Pubmed]
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