The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Gene Review

LOC445737  -  cionin

Ciona intestinalis

 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of LOC445737

  • Sequence-specific immunochemical analysis showed that the cionin gene is expressed also at peptide level in both the gut and the neural ganglion [1].
 

High impact information on LOC445737

 

Anatomical context of LOC445737

  • The sulfated peptides induced concentration-dependent contractions of isolated strips of gallbladder with equal efficacy and similar potencies [ED50: 42 (cionin), 23 (CCK-8-s), and 74 nM (gastrin-17-s)], significantly different from the nonsulfated forms [ED50: 1.7 (CCK-8-ns) and 1.9 microM (gastrin-17-ns)] [5].
 

Associations of LOC445737 with chemical compounds

 

Analytical, diagnostic and therapeutic context of LOC445737

References

  1. cDNA deduced procionin. Structure and expression in protochordates resemble that of procholecystokinin in mammals. Monstein, H.J., Thorup, J.U., Folkesson, R., Johnsen, A.H., Rehfeld, J.F. FEBS Lett. (1993) [Pubmed]
  2. Cionin: a disulfotyrosyl hybrid of cholecystokinin and gastrin from the neural ganglion of the protochordate Ciona intestinalis. Johnsen, A.H., Rehfeld, J.F. J. Biol. Chem. (1990) [Pubmed]
  3. Genomic structure of the gene encoding cionin--a cholecystokinin/gastrin like peptide. Monstein, H.J. Neuroreport (1995) [Pubmed]
  4. Neuroendocrinology of protochordates: insights from Ciona genomics. Sherwood, N.M., Tello, J.A., Roch, G.J. Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. (2006) [Pubmed]
  5. Stimulation of rainbow trout gallbladder contraction by cionin, an ancestral member of the CCK/gastrin family. Schjoldager, B., Jørgensen, J.C., Johnsen, A.H. Gen. Comp. Endocrinol. (1995) [Pubmed]
  6. Molecular cloning of a putative Ciona intestinalis cionin receptor, a new member of the CCK/gastrin receptor family. Nilsson, I.B., Svensson, S.P., Monstein, H.J. Gene (2003) [Pubmed]
 
WikiGenes - Universities