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Gene Review:

ran - RAN, member RAS oncogene family

Xenopus (Silurana) tropicalis

Synonyms: RanTC4, ara24, gsp1, ran-1, tc4

Nachury, M.V. et al., Saitoh, H. et al., Saitoh, H. et al., Zhang, C. et al., Hetzer, M. et al., et al.

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High impact information on ran

The GTPase Ran has recently been shown to stimulate microtubule polymerization in mitotic extracts, but its mode of action is not understood [1].
Although nuclear envelope (NE) assembly is known to require the GTPase Ran, the membrane fusion machinery involved is uncharacterized [2].
The GTPase Ran regulates chromosome positioning and nuclear envelope assembly in vivo [3].
The control of NE assembly is poorly understood, but in a cell-free system made from Xenopus eggs, NE assembly involves the small GTPase Ran [4].
Ran-binding protein 2 (p340(RanBP2)) is a nuclear pore protein [3] [4], and p88(RanGAP1) is a modified form of RanGAP1, a GTPase-activating protein for the small GTPase Ran [2] [5].

Anatomical context of ran

Direct and indirect association of the small GTPase ran with nuclear pore proteins and soluble transport factors: studies in Xenopus laevis egg extracts [6].

References

Importin beta is a mitotic target of the small GTPase Ran in spindle assembly. Nachury, M.V., Maresca, T.J., Salmon, W.C., Waterman-Storer, C.M., Heald, R., Weis, K. Cell (2001) [Pubmed]
Distinct AAA-ATPase p97 complexes function in discrete steps of nuclear assembly. Hetzer, M., Meyer, H.H., Walther, T.C., Bilbao-Cortes, D., Warren, G., Mattaj, I.W. Nat. Cell Biol. (2001) [Pubmed]
The GTPase Ran regulates chromosome positioning and nuclear envelope assembly in vivo. Bamba, C., Bobinnec, Y., Fukuda, M., Nishida, E. Curr. Biol. (2002) [Pubmed]
Role of importin-beta in the control of nuclear envelope assembly by Ran. Zhang, C., Hutchins, J.R., Mühlhäusser, P., Kutay, U., Clarke, P.R. Curr. Biol. (2002) [Pubmed]
Ubc9p and the conjugation of SUMO-1 to RanGAP1 and RanBP2. Saitoh, H., Sparrow, D.B., Shiomi, T., Pu, R.T., Nishimoto, T., Mohun, T.J., Dasso, M. Curr. Biol. (1998) [Pubmed]
Direct and indirect association of the small GTPase ran with nuclear pore proteins and soluble transport factors: studies in Xenopus laevis egg extracts. Saitoh, H., Cooke, C.A., Burgess, W.H., Earnshaw, W.C., Dasso, M. Mol. Biol. Cell (1996) [Pubmed]

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AgaP_AGAP007699	Anopheles gambiae str. PEST
RAN-1	Arabidopsis thaliana
RAN3	Arabidopsis thaliana
RAN2	Arabidopsis thaliana
AGOS_AGR294C	Ashbya gossypii ATCC 10895
RAN	Bos taurus
ran-1	Caenorhabditis elegans
RAN	Canis lupus familiaris
ran	Danio rerio
Ran	Drosophila melanogaster
RAN	Gallus gallus
RAN	Homo sapiens
KLLA0A04499g	Kluyveromyces lactis NRRL Y-1140
KLLA0C05126g	Kluyveromyces lactis NRRL Y-1140
RAN	Macaca mulatta
MGG_09952	Magnaporthe oryzae 70-15
Ran	Mus musculus
NCU09269	Neurospora crassa OR74A
Os01g0611100	Oryza sativa Japonica Group
RAN	Pan troglodytes
Ran	Rattus norvegicus
GSP1	Saccharomyces cerevisiae S288c
GSP2	Saccharomyces cerevisiae S288c
spi1	Schizosaccharomyces pombe 972h-

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