Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

GSP2 - Ran GTPase GSP2

Saccharomyces cerevisiae S288c

Synonyms: CNR2, GTP-binding nuclear protein GSP2/CNR2, YOR185C

Belhumeur, P. et al., Lau, D. et al., Kadowaki, T. et al., Belhumeur, P. et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on GSP2

Since RCC1p acts as GNRP for Ran, a small nuclear GTPase of the ras superfamily, we have identified two homologs of Ran in S.cerevisiae (CNR1 and CNR2) [1].
During the sequencing of the gene GSP2 from Saccharomyces cerevisiae, we have encountered an adjacent open reading frame having strong homology to the 3-phosphoserine aminotransferase (E.C.2.6.1.52) from other organisms [2].

Biological context of GSP2

The small GTPase Ran (encoded by GSP1 and GSP2 in yeast) plays a central role in nucleocytoplasmic transport [3].
GSP1 is an essential gene, and GSP2 is not required for cell viability [4].

Regulatory relationships of GSP2

GSP1 and GSP2 were tagged with protein A and functionally expressed in a gsp1 null mutant [3].

References

Regulation of RNA processing and transport by a nuclear guanine nucleotide release protein and members of the Ras superfamily. Kadowaki, T., Goldfarb, D., Spitz, L.M., Tartakoff, A.M., Ohno, M. EMBO J. (1993) [Pubmed]
A gene from Saccharomyces cerevisiae which codes for a protein with significant homology to the bacterial 3-phosphoserine aminotransferase. Belhumeur, P., Fortin, N., Clark, M.W. Yeast (1994) [Pubmed]
Purification of protein A-tagged yeast ran reveals association with a novel karyopherin beta family member, Pdr6p. Lau, D., Künzler, M., Braunwarth, A., Hellmuth, K., Podtelejnikov, A., Mann, M., Hurt, E. J. Biol. Chem. (2000) [Pubmed]
GSP1 and GSP2, genetic suppressors of the prp20-1 mutant in Saccharomyces cerevisiae: GTP-binding proteins involved in the maintenance of nuclear organization. Belhumeur, P., Lee, A., Tam, R., DiPaolo, T., Fortin, N., Clark, M.W. Mol. Cell. Biol. (1993) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

AgaP_AGAP007699	Anopheles gambiae str. PEST
RAN3	Arabidopsis thaliana
RAN-1	Arabidopsis thaliana
RAN2	Arabidopsis thaliana
AGOS_AGR294C	Ashbya gossypii ATCC 10895
RAN	Bos taurus
ran-1	Caenorhabditis elegans
RAN	Canis lupus familiaris
ran	Danio rerio
Ran	Drosophila melanogaster
RAN	Gallus gallus
RAN	Homo sapiens
KLLA0C05126g	Kluyveromyces lactis NRRL Y-1140
KLLA0A04499g	Kluyveromyces lactis NRRL Y-1140
RAN	Macaca mulatta
MGG_09952	Magnaporthe oryzae 70-15
Ran	Mus musculus
NCU09269	Neurospora crassa OR74A
Os01g0611100	Oryza sativa Japonica Group
RAN	Pan troglodytes
Ran	Rattus norvegicus
GSP1	Saccharomyces cerevisiae S288c
spi1	Schizosaccharomyces pombe 972h-
ran	Xenopus (Silurana) tropicalis

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.