Gene Review:
Ran - RAN, member RAS oncogene family
Rattus norvegicus
Synonyms:
GTP-binding nuclear protein Ran, GTPase Ran, Ras-like protein TC4, Ras-related nuclear protein
- TOR kinase and Ran are downstream from PI3K/Akt in H2O2-induced mitosis. Radisavljevic, Z.M., González-Flecha, B. J. Cell. Biochem. (2004)
- Hydrogen peroxide inhibition of nuclear protein import is mediated by the mitogen-activated protein kinase, ERK2. Czubryt, M.P., Austria, J.A., Pierce, G.N. J. Cell Biol. (2000)
- Protein export from the nucleus requires the GTPase Ran and GTP hydrolysis. Moroianu, J., Blobel, G. Proc. Natl. Acad. Sci. U.S.A. (1995)
- Dissecting the interactions between NTF2, RanGDP, and the nucleoporin XFXFG repeats. Chaillan-Huntington, C., Braslavsky, C.V., Kuhlmann, J., Stewart, M. J. Biol. Chem. (2000)
- Ran binding domains promote the interaction of Ran with p97/beta-karyopherin, linking the docking and translocation steps of nuclear import. Lounsbury, K.M., Richards, S.A., Perlungher, R.R., Macara, I.G. J. Biol. Chem. (1996)
- RanGTP targets p97 to RanBP2, a filamentous protein localized at the cytoplasmic periphery of the nuclear pore complex. Delphin, C., Guan, T., Melchior, F., Gerace, L. Mol. Biol. Cell (1997)
- Molecular interactions between the importin alpha/beta heterodimer and proteins involved in vertebrate nuclear protein import. Percipalle, P., Clarkson, W.D., Kent, H.M., Rhodes, D., Stewart, M. J. Mol. Biol. (1997)
- Ran, a GTP-binding protein involved in nucleocytoplasmic transport and microtubule nucleation, relocates from the manchette to the centrosome region during rat spermiogenesis. Kierszenbaum, A.L., Gil, M., Rivkin, E., Tres, L.L. Mol. Reprod. Dev. (2002)
- Nuclear import of influenza virus RNA can be mediated by viral nucleoprotein and transport factors required for protein import. O'Neill, R.E., Jaskunas, R., Blobel, G., Palese, P., Moroianu, J. J. Biol. Chem. (1995)
- A T42A Ran mutation: differential interactions with effectors and regulators, and defect in nuclear protein import. Murphy, G.A., Moore, M.S., Drivas, G., Pérez de la Ossa, P., Villamarin, A., D'Eustachio, P., Rush, M.G. Mol. Biol. Cell (1997)
- Novel properties of the nucleolar targeting signal of human angiogenin. Lixin, R., Efthymiadis, A., Henderson, B., Jans, D.A. Biochem. Biophys. Res. Commun. (2001)
- Structural basis for molecular recognition between nuclear transport factor 2 (NTF2) and the GDP-bound form of the Ras-family GTPase Ran. Stewart, M., Kent, H.M., McCoy, A.J. J. Mol. Biol. (1998)