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MTNR1B  -  melatonin receptor 1B

Homo sapiens

Synonyms: FGQTL2, MEL-1B-R, MT2, Mel-1B-R, Mel1b receptor, ...
 
 
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Disease relevance of MTNR1B

 

High impact information on MTNR1B

  • PCR analysis of human-rodent somatic cell hybrids maps the Mel1b receptor gene (MTNR1B) to human chromosome 11q21-22 [2].
  • The Mel1b melatonin receptor may mediate the reported actions of melatonin in retina and participate in some of the neurobiological effects of melatonin in mammals [2].
  • Functional studies of NIH 3T3 cells stably expressing the Mel1b melatonin receptor indicate that it is coupled to inhibition of adenylyl cyclase [2].
  • Comparative reverse transcription PCR shows that the Mel1b melatonin receptor is expressed in retina and, to a lesser extent, brain [2].
  • Although no statistically significant difference in allele frequency between RF(+) and controls was observed (chi2 = 2.75, P = 0.10), the results might suggest that MTNR1B SNP (rs 1562444) is associated with the presence of RF in RA [3].
 

Biological context of MTNR1B

  • Using haplotype block tagging technique, a set of tagging SNPs were defined for MTNR1B from the Han Chinese data of the International HapMap project [4].
  • Further analysis of the remaining tSNPs within the regulatory region of the MTNR1B gene and other related genes in the melatonin signaling pathway may provide further information on the role of the melatonin in AIS girls [4].
 

Associations of MTNR1B with chemical compounds

  • However, six agonists showed 10 to 60 fold higher affinity for the Mel1b melatonin receptor as indicated by the affinity selectivity ratios (Mel1a/Mel1b) [8-methoxy-2-acetamidotetraline (11); S20098 (14); 8-methoxy-2-propionamidotetraline (20); 6, 7 di-chloro-2-methylmelatonin (21); 6-chloromelatonin (57); 6-methoxymelatonin (59)] [5].
  • The binding was inhibited by Mel1b melatonin receptor antagonists, luzindole and 4-phenyl-2-propionamidotetralin (4-P-PDOT) as well as by non-hydrolyzable analogs of GTP like GTPgammaS and Gpp(NH)p but not by adenosine nucleotides [6].

References

  1. Melatonin receptors in human uveal melanocytes and melanoma cells. Roberts, J.E., Wiechmann, A.F., Hu, D.N. J. Pineal Res. (2000) [Pubmed]
  2. Molecular characterization of a second melatonin receptor expressed in human retina and brain: the Mel1b melatonin receptor. Reppert, S.M., Godson, C., Mahle, C.D., Weaver, D.R., Slaugenhaupt, S.A., Gusella, J.F. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  3. Positive relationship between melatonin receptor type 1B polymorphism and rheumatoid factor in rheumatoid arthritis patients in the Korean population. Ha, E., Choe, B.K., Jung, K.H., Yoon, S.H., Park, H.J., Park, H.K., Yim, S.V., Chung, J.H., Bae, H.S., Nam, M., Baik, H.H., Hong, S.J. J. Pineal Res. (2005) [Pubmed]
  4. The Role of Melatonin Receptor 1B Gene (MTNR1B) in Adolescent Idiopathic Scoliosis - A Genetic Association Study. Qiu, X.S., Tang, N.L., Yeung, H.Y., Qiu, Y., Qin, L., Lee, K.M., Cheng, J.C. Studies in health technology and informatics (2006) [Pubmed]
  5. Melatonin receptor antagonists that differentiate between the human Mel1a and Mel1b recombinant subtypes are used to assess the pharmacological profile of the rabbit retina ML1 presynaptic heteroreceptor. Dubocovich, M.L., Masana, M.I., Iacob, S., Sauri, D.M. Naunyn Schmiedebergs Arch. Pharmacol. (1997) [Pubmed]
  6. Receptor-mediated modulation of avian caecal muscle contraction by melatonin: role of tyrosine protein kinase. Poon, A.M., Kravtsov, G.M., Pang, S.F. J. Pineal Res. (2002) [Pubmed]
 
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