Psychiatry related information on DLA-DQB1

• There was no strong positive or negative correlation between the development of narcolepsy and specific DLA-DQB1 alleles [1].

High impact information on DLA-DQB1

• No new DQA1 alleles were recognized among the three dog populations, but five novel DLA-DRB1 and 2 novel DLA-DQB1 allele sequences were detected [2].
• DNA from 460 cases and 1047 controls were genotyped for DLA-DRB1, DLA-DQA1 and DLA-DQB1 using sequence-based typing [3].
• DLA-DQB1 alleles and bone marrow transplantation experiments in narcoleptic dogs [1].
• DLA-DRB1 and DLA-DQB1 histocompatibility typing by PCR-SSCP and sequencing [4].

Biological context of DLA-DQB1

• In this study polymerase chain reaction-single-stranded conformational polymorphism is used to separate alleles thereby allowing sequenced-based typing of the two most polymorphic class II genes described to date in the dog DLA-DRB1 and DLA-DQB1 [4].
• Analyses of the nucleotide sequences and of the serological and cellular typing data revealed that phenotypic homozygosity, as defined by the DLA-D type in mixed leukocyte culture (MLC), tended to correlate with homozygosity at the DLA-DRB1 locus but not necessarily at the DLA-DQB1 locus [5].

Associations of DLA-DQB1 with chemical compounds

• In the class II region there is one complete DRB gene called DLA-DRB1 with at least 24 alleles and one full-length DQB gene, DLA-DQB1, with 20 alleles characterized to date [6].

Other interactions of DLA-DQB1

• Forty per cent of dogs typed were homozygous at DLA-DRB1, 52% at DLA-DQA1 and 44% at DLA-DQB1 [7].

References