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Gene Review

bgcn  -  benign gonial cell neoplasm

Drosophila melanogaster

Synonyms: BGCN, Benign gonial cell neoplasm protein, Bgcn, CG10330, CG10331, ...
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Disease relevance of bgcn


High impact information on bgcn

  • Here we investigate how bam and bgcn regulate the male germline stem cell lineage [2].
  • Taken together, our results suggest that bam and bgcn regulate progression through the male germline stem cell lineage by cell-intrinsically restricting the proliferation of amplifying germ cells [2].
  • By generating FLP-mediated clones, we demonstrate that both bam and bgcn act autonomously in the germline to restrict proliferation during spermatogenesis [2].
  • Cessation of mitotic proliferation and onset of the meiotic program is regulated by the bam and bgcn genes acting within male germ cells and a TGF-beta class signaling cascade in surrounding somatic cells [3].
  • Also, mutations in bgcn dominantly enhance a bam mutant phenotype, further corroborating the interdependence of these two genes' functions [4].

Biological context of bgcn


Anatomical context of bgcn

  • The data indicate that, like bam, bgcn is required for cystoblast development and that germ cells lacking bgcn become trapped in a stem cell-like state [7].
  • Misexpression of Bam eliminates wild-type stem cells, apparently by inducing them to divide as cystoblasts. bgcn stem cells remain active when Bam is misexpressed, probably because they cannot adopt the cystoblast fate [7].

Other interactions of bgcn


  1. Drosophila differentiation genes instrumental in tumor suppression. Gateff, E., Kurzik-Dumke, U., Wismar, J., Löffler, T., Habtemichael, N., Konrad, L., Dreschers, S., Kaiser, S., Protin, U. Int. J. Dev. Biol. (1996) [Pubmed]
  2. bag-of-marbles and benign gonial cell neoplasm act in the germline to restrict proliferation during Drosophila spermatogenesis. Gönczy, P., Matunis, E., DiNardo, S. Development (1997) [Pubmed]
  3. Genetic control of cell proliferation and differentiation in Drosophila spermatogenesis. Fuller, M.T. Semin. Cell Dev. Biol. (1998) [Pubmed]
  4. The Drosophila cystoblast differentiation factor, benign gonial cell neoplasm, is related to DExH-box proteins and interacts genetically with bag-of-marbles. Ohlstein, B., Lavoie, C.A., Vef, O., Gateff, E., McKearin, D.M. Genetics (2000) [Pubmed]
  5. Sex determination of germ cells in Drosophila. Mahowald, A.P., Wei, G. Ciba Found. Symp. (1994) [Pubmed]
  6. Recurrent Positive Selection at Bgcn, a Key Determinant of Germ Line Differentiation, Does Not Appear to be Driven by Simple Coevolution with Its Partner Protein Bam. Bauer Dumont, V.L., Flores, H.A., Wright, M.H., Aquadro, C.F. Mol. Biol. Evol. (2007) [Pubmed]
  7. Localization and function of Bam protein require the benign gonial cell neoplasm gene product. Lavoie, C.A., Ohlstein, B., McKearin, D.M. Dev. Biol. (1999) [Pubmed]
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