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FLT3  -  fms-related tyrosine kinase 3

Canis lupus familiaris

 
 
 
 
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Disease relevance of FLT3

 

High impact information on FLT3

  • All engrafted FL-treated dogs became stable complete (n=2) or mixed (n=6) hematopoietic chimeras without significant graft-versus-host disease (GVHD) [1].
  • RESULTS: In normal dogs, FL produced significant increases in monocytes (CD14+) and neutrophils in the peripheral blood, a marked increase in CD1c+ cells with DC-type morphology in lymph nodes, and increased alloreactivity of third-party responders to peripheral blood mononuclear cells in mixed lymphocyte reactions (P<0.001) [1].
  • It was hypothesized that the in vivo expansion of recipient dendritic cells (DC) with the administration of ligand for Flt3 (FL) could promote allogeneic engraftment after reduced-intensity conditioning by enhancing the GVH effect [1].

References

  1. FLT3 ligand promotes engraftment of allogeneic hematopoietic stem cells without significant graft-versus-host disease. Yunusov, M.Y., Georges, G.E., Storb, R., Moore, P., Hagglund, H., Affolter, V., Lesnikova, M., Gass, M.J., Little, M.T., Loken, M., McKenna, H., Storer, B., Nash, R.A. Transplantation (2003) [Pubmed]
 
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