Gene Review:
Flt3 - FMS-like tyrosine kinase 3
Mus musculus
Synonyms:
B230315G04, CD135, FL cytokine receptor, FLK-2, FLT-3, ...
Takahashi,
Carter,
Feingold,
Oh,
Kirman,
Wildbrett,
Stapleton,
Asi,
Fowler,
Bhagat,
Huang,
Fine,
Whelan,
Björck,
Lie,
Woulfe,
Klein,
Olson,
Storkus,
Wolf,
Rohrschneider,
Pandey,
Volkots,
Seroogy,
Rose,
Yu,
Lambing,
Hutchaleelaha,
Hollenbach,
Abe,
Giese,
Scarborough,
Voutsadakis,
Fukuda,
Pelus,
Karsunky,
Merad,
Cozzio,
Weissman,
Manz,
- Bis(1H-2-indolyl)-1-methanones as inhibitors of the hematopoietic tyrosine kinase Flt3. Teller, S., Krämer, D., Böhmer, S.A., Tse, K.F., Small, D., Mahboobi, S., Wallrapp, C., Beckers, T., Kratz-Albers, K., Schwäble, J., Serve, H., Böhmer, F.D. Leukemia (2002)
- Perioperative immunomodulation with Flt3 kinase ligand or a whole tumor cell vaccine is associated with a reduction in lung metastasis formation after laparotomy in mice. Carter, J.J., Feingold, D.L., Oh, A., Kirman, I., Wildbrett, P., Stapleton, G., Asi, Z., Fowler, R., Bhagat, G., Huang, E.H., Fine, R.L., Whelan, R.L. Surgical innovation. (2006)
- Combinational FLt3 ligand and granulocyte macrophage colony-stimulating factor treatment promotes enhanced tumor infiltration by dendritic cells and antitumor CD8(+) T-cell cross-priming but is ineffective as a therapy. Berhanu, A., Huang, J., Alber, S.M., Watkins, S.C., Storkus, W.J. Cancer Res. (2006)
- Rapamycin inhibits IL-4--induced dendritic cell maturation in vitro and dendritic cell mobilization and function in vivo. Hackstein, H., Taner, T., Zahorchak, A.F., Morelli, A.E., Logar, A.J., Gessner, A., Thomson, A.W. Blood (2003)
- Flt3 in acute myelogenous leukemia: biology, prognosis, and therapeutic implications. Voutsadakis, I.A. Med. Oncol. (2003)
- A receptor tyrosine kinase specific to hematopoietic stem and progenitor cell-enriched populations. Matthews, W., Jordan, C.T., Wiegand, G.W., Pardoll, D., Lemischka, I.R. Cell (1991)
- Upregulation of Flt3 expression within the bone marrow Lin(-)Sca1(+)c-kit(+) stem cell compartment is accompanied by loss of self-renewal capacity. Adolfsson, J., Borge, O.J., Bryder, D., Theilgaard-Mönch, K., Astrand-Grundström, I., Sitnicka, E., Sasaki, Y., Jacobsen, S.E. Immunity (2001)
- Early hematopoietic lineage restrictions directed by Ikaros. Yoshida, T., Yao-Ming Ng, S., Zuniga-Pflucker, J.C., Georgopoulos, K. Nat. Immunol. (2006)
- Thymic stromal-derived lymphopoietin distinguishes fetal from adult B cell development. Vosshenrich, C.A., Cumano, A., Müller, W., Di Santo, J.P., Vieira, P. Nat. Immunol. (2003)
- Effects of MLN518, a dual FLT3 and KIT inhibitor, on normal and malignant hematopoiesis. Griswold, I.J., Shen, L.J., La Rosée, P., Demehri, S., Heinrich, M.C., Braziel, R.M., McGreevey, L., Haley, A.D., Giese, N., Druker, B.J., Deininger, M.W. Blood (2004)
- Microchimerism, donor dendritic cells, and alloimmune reactivity in recipients of Flt3 ligand-mobilized hemopoietic cells: modulation by tacrolimus. Morelli, A.E., Antonysamy, M.A., Takayama, T., Hackstein, H., Chen, Z., Qian, S., Zurowski, N.B., Thomson, A.W. J. Immunol. (2000)
- Fiz1, a novel zinc finger protein interacting with the receptor tyrosine kinase Flt3. Wolf, I., Rohrschneider, L.R. J. Biol. Chem. (1999)
- Murine Flt3, a gene encoding a novel tyrosine kinase receptor of the PDGFR/CSF1R family. Rosnet, O., Marchetto, S., deLapeyriere, O., Birnbaum, D. Oncogene (1991)
- Chromosomal localization of FLT4, a novel receptor-type tyrosine kinase gene. Galland, F., Karamysheva, A., Mattei, M.G., Rosnet, O., Marchetto, S., Birnbaum, D. Genomics (1992)
- Internal tandem duplication of Flt3 modulates chemotaxis and survival of hematopoietic cells by SDF1alpha but negatively regulates marrow homing in vivo. Fukuda, S., Pelus, L.M. Exp. Hematol. (2006)
- Flt3 ligand regulates dendritic cell development from Flt3+ lymphoid and myeloid-committed progenitors to Flt3+ dendritic cells in vivo. Karsunky, H., Merad, M., Cozzio, A., Weissman, I.L., Manz, M.G. J. Exp. Med. (2003)
- Inhibition of natural type I IFN-producing and dendritic cell development by a small molecule receptor tyrosine kinase inhibitor with Flt3 affinity. Tussiwand, R., Onai, N., Mazzucchelli, L., Manz, M.G. J. Immunol. (2005)
- Marrow sensitization to 5-fluorouracil using the ligands for Flt-3 and c-Kit. Jin, L., Neff, T., Blau, C.A. Exp. Hematol. (1999)
- Identification of orally active, potent, and selective 4-piperazinylquinazolines as antagonists of the platelet-derived growth factor receptor tyrosine kinase family. Pandey, A., Volkots, D.L., Seroogy, J.M., Rose, J.W., Yu, J.C., Lambing, J.L., Hutchaleelaha, A., Hollenbach, S.J., Abe, K., Giese, N.A., Scarborough, R.M. J. Med. Chem. (2002)
- Flt3 mutations from patients with acute myeloid leukemia induce transformation of 32D cells mediated by the Ras and STAT5 pathways. Mizuki, M., Fenski, R., Halfter, H., Matsumura, I., Schmidt, R., Müller, C., Grüning, W., Kratz-Albers, K., Serve, S., Steur, C., Büchner, T., Kienast, J., Kanakura, Y., Berdel, W.E., Serve, H. Blood (2000)
- Progenipoietin-generated dendritic cells exhibit anti-tumor efficacy in a therapeutic murine tumor model. Björck, P., Lie, W.R., Woulfe, S.L., Klein, B.K., Olson, W., Storkus, W.J. Int. J. Cancer (2002)
- Myeloid progenitor cell regulatory effects of vascular endothelial cell growth factor. Broxmeyer, H.E., Cooper, S., Li, Z.H., Lu, L., Song, H.Y., Kwon, B.S., Warren, R.E., Donner, D.B. Int. J. Hematol. (1995)
- Soluble thrombopoietin receptor (Mpl) and granulocyte colony-stimulating factor receptor directly stimulate proliferation of primitive hematopoietic progenitors of mice in synergy with steel factor or the ligand for Flt3/Flk2. Ku, H., Hirayama, F., Kato, T., Miyazaki, H., Aritomi, M., Ota, Y., D'Andrea, A.D., Lyman, S.D., Ogawa, M. Blood (1996)
- Flt3 ligand can promote survival and macrophage development without proliferation in myeloid progenitor cells. Nicholls, S.E., Winter, S., Mottram, R., Miyan, J.A., Whetton, A.D. Exp. Hematol. (1999)
- Fms-like tyrosine kinase 3 catalytic domain can transduce a proliferative signal in FDC-P1 cells that is qualitatively similar to the signal delivered by c-Fms. Rossner, M.T., McArthur, G.A., Allen, J.D., Metcalf, D. Cell Growth Differ. (1994)
- Expression of Flt3 tyrosine kinase receptor gene in mouse hematopoietic and nervous tissues. deLapeyrière, O., Naquet, P., Planche, J., Marchetto, S., Rottapel, R., Gambarelli, D., Rosnet, O., Birnbaum, D. Differentiation (1995)
- Identification of Flt3 internal tandem duplications downstream targets by high-throughput immunoblotting protein array system. Takahashi, S. Am. J. Hematol. (2006)
- Normal donor bone marrow is superior to Flt3 ligand-mobilized bone marrow in prolonging heart allograft survival when combined with anti-CD40L (CD154). Hackstein, H., Wang, Z., Morelli, A.E., Kaneko, K., Takayama, T., Colvin, B.L., Bein, G., Thomson, A.W. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. (2002)
- Emerging Flt3 kinase inhibitors in the treatment of leukaemia. Tickenbrock, L., Müller-Tidow, C., Berdel, W.E., Serve, H. Expert opinion on emerging drugs. (2006)