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Dpml  -  dopamine loss

Mus musculus

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Disease relevance of Dpml


Psychiatry related information on Dpml

  • In the present manuscript, we report on the characterization of amphetamine-induced locomotor activity as a sensitive functional endpoint for dopamine loss following MPTP treatment [4].

High impact information on Dpml

  • The ability of low ambient temperature, or of the specific neuronal nitric oxide synthase (nNOS) inhibitor AR-R17477AR, to protect against both long-term striatal NF68 and dopamine loss induced by METH (3 mg/kg, i.p.) was also studied [5].
  • We administered different doses of methamphetamine either to DSP-4-pretreated or to intact Swiss-Webster mice and evaluated the methamphetamine-induced striatal dopamine loss at early and prolonged intervals [6].
  • The magnitude of dopamine loss measurable is dependent on the genetic background of the mouse strain used, the basal ganglia subregion examined, and the age of the animals at assessment [1].
  • In this study, we investigated whether the exacerbation of chronic dopamine loss in DSP-4-pretreated animals is due to an impairment in the recovery of dopamine levels once the neurotoxic insult is generated or to an increased efficacy of the effects induced by methamphetamine [6].
  • Increased tyrosine hydroxylase enzyme activity compensated for striatal tyrosine hydroxylase protein and/or dopamine loss following treatment in 6-week-old and 5-month-old, but not 18-month-old paraquat and paraquat + maneb mice [7].

Chemical compound and disease context of Dpml


Anatomical context of Dpml


Associations of Dpml with chemical compounds


Analytical, diagnostic and therapeutic context of Dpml


  1. Influence of age and strain on striatal dopamine loss in a genetic mouse model of Lesch-Nyhan disease. Jinnah, H.A., Jones, M.D., Wojcik, B.E., Rothstein, J.D., Hess, E.J., Friedmann, T., Breese, G.R. J. Neurochem. (1999) [Pubmed]
  2. Astroglial plasticity and glutamate function in a chronic mouse model of Parkinson's disease. Dervan, A.G., Meshul, C.K., Beales, M., McBean, G.J., Moore, C., Totterdell, S., Snyder, A.K., Meredith, G.E. Exp. Neurol. (2004) [Pubmed]
  3. In mice, production of plasma IL-1 and IL-6 in response to MPTP is related to behavioral lateralization. Shen, Y.Q., Hebert, G., Su, Y., Moze, E., Neveu, P.J., Li, K.S. Brain Res. (2005) [Pubmed]
  4. Amphetamine-induced locomotor activity is reduced in mice following MPTP treatment but not following selegiline/MPTP treatment. West, B.D., Shughrue, P.J., Vanko, A.E., Ransom, R.W., Kinney, G.G. Pharmacol. Biochem. Behav. (2006) [Pubmed]
  5. The nNOS inhibitor, AR-R17477AR, prevents the loss of NF68 immunoreactivity induced by methamphetamine in the mouse striatum. Sanchez, V., Zeini, M., Camarero, J., O'Shea, E., Bosca, L., Green, A.R., Colado, M.I. J. Neurochem. (2003) [Pubmed]
  6. Effects of pretreatment with N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP-4) on methamphetamine pharmacokinetics and striatal dopamine losses. Fornai, F., Giorgi, F.S., Alessandrì, M.G., Giusiani, M., Corsini, G.U. J. Neurochem. (1999) [Pubmed]
  7. Age-related irreversible progressive nigrostriatal dopaminergic neurotoxicity in the paraquat and maneb model of the Parkinson's disease phenotype. Thiruchelvam, M., McCormack, A., Richfield, E.K., Baggs, R.B., Tank, A.W., Di Monte, D.A., Cory-Slechta, D.A. Eur. J. Neurosci. (2003) [Pubmed]
  8. Tetrahydrobiopterin deficiency and dopamine loss in a genetic mouse model of Lesch-Nyhan disease. Hyland, K., Kasim, S., Egami, K., Arnold, L.A., Jinnah, H.A. J. Inherit. Metab. Dis. (2004) [Pubmed]
  9. GM1 ganglioside rescues substantia nigra pars compacta neurons and increases dopamine synthesis in residual nigrostriatal dopaminergic neurons in MPTP-treated mice. Schneider, J.S., Kean, A., DiStefano, L. J. Neurosci. Res. (1995) [Pubmed]
  10. A study of the mechanisms involved in the neurotoxic action of 3,4-methylenedioxymethamphetamine (MDMA, 'ecstasy') on dopamine neurones in mouse brain. Colado, M.I., Camarero, J., Mechan, A.O., Sanchez, V., Esteban, B., Elliott, J.M., Green, A.R. Br. J. Pharmacol. (2001) [Pubmed]
  11. Time-course and dose-response study on the effects of chronic L-DOPA administration on striatal dopamine levels and dopamine transporter following MPTP toxicity. Fornai, F., Battaglia, G., Gesi, M., Giorgi, F.S., Orzi, F., Nicoletti, F., Ruggieri, S. Brain Res. (2000) [Pubmed]
  12. gamma-Tocopherol attenuates MPTP-induced dopamine loss more efficiently than alpha-tocopherol in mouse brain. Itoh, N., Masuo, Y., Yoshida, Y., Cynshi, O., Jishage, K., Niki, E. Neurosci. Lett. (2006) [Pubmed]
  13. Norepinephrine loss selectively enhances chronic nigrostriatal dopamine depletion in mice and rats. Fornai, F., Torracca, M.T., Bassi, L., D'Errigo, D.A., Scalori, V., Corsini, G.U. Brain Res. (1996) [Pubmed]
  14. Ovarian steroids and raloxifene prevent MPTP-induced dopamine depletion in mice. Grandbois, M., Morissette, M., Callier, S., Di Paolo, T. Neuroreport (2000) [Pubmed]
  15. MK-801 fails to protect against the dopaminergic neuropathology produced by systemic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice or intranigral 1-methyl-4-phenylpyridinium in rats. Sonsalla, P.K., Zeevalk, G.D., Manzino, L., Giovanni, A., Nicklas, W.J. J. Neurochem. (1992) [Pubmed]
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