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SPRN  -  shadow of prion protein homolog (zebrafish)

Homo sapiens

Synonyms: FLJ41197, Protein shadoo, SHADOO, SHO, Shadoo, ...
 
 
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High impact information on SPRN

  • Phylogenetic footprinting performed on aligned human, mouse, and Fugu SPRN genes to define candidate regulatory promoter regions, detected 16 conserved motifs, three of which are known transcription factor-binding sites for a receptor and transcription factors specific to or associated with expression in brain [1].
  • This result and other homology-based (VISTA global genomic alignment; protein sequence alignment and phylogenetics) and context-dependent (genomic context; relative gene order and orientation) criteria indicate fish and mammalian SPRN genes are orthologous and suggest a strongly conserved basic function in brain [1].
  • SPRN comprises two exons, with the open reading frame (ORF) contained within exon 2, and codes for a protein of 130-150 amino acids named Shadoo (Japanese shadow), predicted to be extracellular and GPI-anchored [2].
  • Database information indicates expression of SPRN in embryo, brain and retina of mouse and rat, hippocampus of human, and in embryo and retina of zebrafish, and we directly confirmed a strikingly specific expression of the mammalian (human, mouse, rat) transcripts in whole brain [2].
  • We report evidence from cDNA isolation and expression analysis as well as analyses of genome, expressed sequence tag (EST), cDNA and expression databases for a new gene named SPRN (shadow of prion protein) [2].
 

Anatomical context of SPRN

 

Analytical, diagnostic and therapeutic context of SPRN

References

  1. Evolution of vertebrate genes related to prion and Shadoo proteins--clues from comparative genomic analysis. Premzl, M., Gready, J.E., Jermiin, L.S., Simonic, T., Marshall Graves, J.A. Mol. Biol. Evol. (2004) [Pubmed]
  2. Shadoo, a new protein highly conserved from fish to mammals and with similarity to prion protein. Premzl, M., Sangiorgio, L., Strumbo, B., Marshall Graves, J.A., Simonic, T., Gready, J.E. Gene (2003) [Pubmed]
  3. Cloning of the bovine prion-like Shadoo (SPRN) gene by comparative analysis of the predicted genomic locus. Uboldi, C., Paulis, M., Guidi, E., Bertoni, A., Meo, G.P., Perucatti, A., Iannuzzi, L., Raimondi, E., Brunner, R.M., Eggen, A., Ferretti, L. Mamm. Genome (2006) [Pubmed]
 
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