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Galns  -  galactosamine (N-acetyl)-6-sulfate sulfatase

Mus musculus

Synonyms: Chondroitinase, Chondroitinsulfatase, GalNAc6S sulfatase, Galactose-6-sulfate sulfatase, N-acetylgalactosamine-6-sulfatase, ...
 
 
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Disease relevance of Galns

 

High impact information on Galns

 

Biological context of Galns

 

Analytical, diagnostic and therapeutic context of Galns

  • Ubiquitous expression of the inactive human GALNS was also confirmed by western blot using the anti-GALNS monoclonal antibodies newly produced, which resulted in tolerance to immune challenge with human enzyme [3].

References

  1. Mouse model of N-acetylgalactosamine-6-sulfate sulfatase deficiency (Galns-/-) produced by targeted disruption of the gene defective in Morquio A disease. Tomatsu, S., Orii, K.O., Vogler, C., Nakayama, J., Levy, B., Grubb, J.H., Gutierrez, M.A., Shim, S., Yamaguchi, S., Nishioka, T., Montano, A.M., Noguchi, A., Orii, T., Kondo, N., Sly, W.S. Hum. Mol. Genet. (2003) [Pubmed]
  2. The mouse N-acetylgalactosamine-6-sulfate sulfatase (Galns) gene: cDNA isolation, genomic characterization, chromosomal assignment and analysis of the 5'-flanking region. Montaño, A.M., Yamagishi, A., Tomatsu, S., Fukuda, S., Copeland, N.G., Orii, K.E., Isogai, K., Yamada, N., Kato, Z.I., Jenkins, N.A., Gilbert, D.J., Sukegawa, K., Orii, T., Kondo, N. Biochim. Biophys. Acta (2000) [Pubmed]
  3. Development of MPS IVA mouse (Galnstm(hC79S.mC76S)slu) tolerant to human N-acetylgalactosamine-6-sulfate sulfatase. Tomatsu, S., Gutierrez, M., Nishioka, T., Yamada, M., Yamada, M., Tosaka, Y., Grubb, J.H., Montaño, A.M., Vieira, M.B., Trandafirescu, G.G., Peña, O.M., Yamaguchi, S., Orii, K.O., Orii, T., Noguchi, A., Laybauer, L. Hum. Mol. Genet. (2005) [Pubmed]
 
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