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Gene Review

TFAM  -  transcription factor A, mitochondrial

Bos taurus

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Disease relevance of TFAM

  • Our results suggest for the first time that TFAM gene plays an important role in lipid metabolism and may be a strong candidate gene for obesity in mammals [1].

High impact information on TFAM


Analytical, diagnostic and therapeutic context of TFAM

  • In the present study, both cDNA (2259 bp) and genomic DNA (16,666 bp) sequences were generated for the bovine TFAM gene using a combination of in silico cloning with targeted region PCR amplification [1].


  1. Significant associations of the mitochondrial transcription factor A promoter polymorphisms with marbling and subcutaneous fat depth in Wagyu x Limousin F2 crosses. Jiang, Z., Kunej, T., Michal, J.J., Gaskins, C.T., Reeves, J.J., Busboom, J.R., Dovc, P., Wright, R.W. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
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