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FKBP11  -  FK506 binding protein 11, 19 kDa

Homo sapiens

Synonyms: 19 kDa FK506-binding protein, 19 kDa FKBP, FK506-binding protein 11, FKBP-11, FKBP-19, ...
 
 
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Disease relevance of FKBP11

  • Ng-MIP, a surface-exposed lipoprotein of Neisseria gonorrhoeae, has a peptidyl-prolyl cis/trans isomerase (PPIase) activity and is involved in persistence in macrophages [1].
  • The PPIase active site of Legionella pneumophila Mip protein is involved in the infection of eukaryotic host cells [2].
 

High impact information on FKBP11

  • These analyses suggest that the FKBP multigene family emerged early in the evolutionary history of eukaryotes, and during that time some members, including the FKBP65 gene, have experienced gene elongation by means of PPIase domain duplication [3].
  • Both families, although dissimilar in sequence, possess peptidyl-prolyl cis-trans isomerase activity in vitro and can play roles in protein folding and transport, RNA splicing and the regulation of multi-protein complexes in cells [4].
  • All but one of the PPIase inhibiting mAbs were able to significantly inhibit the early establishment and initiation of an intracellular infection of the bacteria in Acanthamoeba castellanii, the natural host, and in the human phagocytic cell line U937 [2].

References

  1. Ng-MIP, a surface-exposed lipoprotein of Neisseria gonorrhoeae, has a peptidyl-prolyl cis/trans isomerase (PPIase) activity and is involved in persistence in macrophages. Leuzzi, R., Serino, L., Scarselli, M., Savino, S., Fontana, M.R., Monaci, E., Taddei, A., Fischer, G., Rappuoli, R., Pizza, M. Mol. Microbiol. (2005) [Pubmed]
  2. The PPIase active site of Legionella pneumophila Mip protein is involved in the infection of eukaryotic host cells. Helbig, J.H., König, B., Knospe, H., Bubert, B., Yu, C., Lück, C.P., Riboldi-Tunnicliffe, A., Hilgenfeld, R., Jacobs, E., Hacker, J., Fischer, G. Biol. Chem. (2003) [Pubmed]
  3. Genomic organization of mouse and human 65 kDa FK506-binding protein genes and evolution of the FKBP multigene family. Patterson, C.E., Gao, J., Rooney, A.P., Davis, E.C. Genomics (2002) [Pubmed]
  4. Peptidyl-prolyl cis-trans isomerases (immunophilins) and their roles in parasite biochemistry, host-parasite interaction and antiparasitic drug action. Bell, A., Monaghan, P., Page, A.P. Int. J. Parasitol. (2006) [Pubmed]
 
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