The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Editor

Share

Personal info

View

Links

  • Homologues
  • NCBI Gene
  • NCBI SNP
  • iHOP resource
  • OMIM
  • SNPedia
  • UniProt
  • Ensembl
  • HGNC

Table of contents

About

Terms

 

Gene Review: 

FKBP11  -  FK506 binding protein 11, 19 kDa

Homo sapiens

Synonyms: 19 kDa FK506-binding protein, 19 kDa FKBP, FK506-binding protein 11, FKBP-11, FKBP-19, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of FKBP11

  • Ng-MIP, a surface-exposed lipoprotein of Neisseria gonorrhoeae, has a peptidyl-prolyl cis/trans isomerase (PPIase) activity and is involved in persistence in macrophages [1].
  • The PPIase active site of Legionella pneumophila Mip protein is involved in the infection of eukaryotic host cells [2].
 

High impact information on FKBP11

  • These analyses suggest that the FKBP multigene family emerged early in the evolutionary history of eukaryotes, and during that time some members, including the FKBP65 gene, have experienced gene elongation by means of PPIase domain duplication [3].
  • Both families, although dissimilar in sequence, possess peptidyl-prolyl cis-trans isomerase activity in vitro and can play roles in protein folding and transport, RNA splicing and the regulation of multi-protein complexes in cells [4].
  • All but one of the PPIase inhibiting mAbs were able to significantly inhibit the early establishment and initiation of an intracellular infection of the bacteria in Acanthamoeba castellanii, the natural host, and in the human phagocytic cell line U937 [2].

References

  1. Ng-MIP, a surface-exposed lipoprotein of Neisseria gonorrhoeae, has a peptidyl-prolyl cis/trans isomerase (PPIase) activity and is involved in persistence in macrophages. Leuzzi, R., Serino, L., Scarselli, M., Savino, S., Fontana, M.R., Monaci, E., Taddei, A., Fischer, G., Rappuoli, R., Pizza, M. Mol. Microbiol. (2005) [Pubmed]
  2. The PPIase active site of Legionella pneumophila Mip protein is involved in the infection of eukaryotic host cells. Helbig, J.H., König, B., Knospe, H., Bubert, B., Yu, C., Lück, C.P., Riboldi-Tunnicliffe, A., Hilgenfeld, R., Jacobs, E., Hacker, J., Fischer, G. Biol. Chem. (2003) [Pubmed]
  3. Genomic organization of mouse and human 65 kDa FK506-binding protein genes and evolution of the FKBP multigene family. Patterson, C.E., Gao, J., Rooney, A.P., Davis, E.C. Genomics (2002) [Pubmed]
  4. Peptidyl-prolyl cis-trans isomerases (immunophilins) and their roles in parasite biochemistry, host-parasite interaction and antiparasitic drug action. Bell, A., Monaghan, P., Page, A.P. Int. J. Parasitol. (2006) [Pubmed]
Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenesOpen Access LicencePrivacy PolicyTerms of Useapsburg
 
WikiGenes - Universities