Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

CLIC1 - chloride intracellular channel 1

Bos taurus

Tulk, B.M. et al., Nishizawa, T. et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on CLIC1

CLIC-1-dependent chloride permeability was inhibited by indanyloxyacetic acid-94 with an apparent IC(50) of 8.6 micrometer [1].
The fusion protein was purified by glutathione affinity, and CLIC-1 was released from its fusion partner by digestion with thrombin [1].
When expressed as a fusion protein with green fluorescent protein (GFP) in the LLC-PK1 kidney cell line, GFP-parchorin, unlike other CLIC family members, existed mainly in the cytosol [2].
Chloride permeability of reconstituted vesicles was assessed using a valinomycin dependent chloride efflux assay, demonstrating increased vesicular chloride permeability with CLIC-1 compared with control [1].

Associations of CLIC1 with chemical compounds

These data convincingly demonstrate that CLIC-1 is capable of forming a novel, chloride-selective channel in the absence of other subunits or proteins [1].

Analytical, diagnostic and therapeutic context of CLIC1

Molecular cloning and characterization of a novel chloride intracellular channel-related protein, parchorin, expressed in water-secreting cells [2].

References

CLIC-1 functions as a chloride channel when expressed and purified from bacteria. Tulk, B.M., Schlesinger, P.H., Kapadia, S.A., Edwards, J.C. J. Biol. Chem. (2000) [Pubmed]
Molecular cloning and characterization of a novel chloride intracellular channel-related protein, parchorin, expressed in water-secreting cells. Nishizawa, T., Nagao, T., Iwatsubo, T., Forte, J.G., Urushidani, T. J. Biol. Chem. (2000) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

DHAR2	Arabidopsis thaliana
DHAR1	Arabidopsis thaliana
CLIC1	Canis lupus familiaris
clic1	Danio rerio
CLIC1	Homo sapiens
Clic1	Mus musculus
Os05g0116100	Oryza sativa Japonica Group
CLIC1	Pan troglodytes
Clic1	Rattus norvegicus
clic1	Xenopus (Silurana) tropicalis

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.