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Gene Review

PDHA2  -  pyruvate dehydrogenase (lipoamide) alpha 2

Homo sapiens

Synonyms: PDHAL, PDHE1-A type II, Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial
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High impact information on PDHA2

  • Given the localization of PDHA and the evidence that its activity correlates positively with hyperactivation and that its PDHA2 subunit exhibits capacitation-associated protein tyrosine phosphorylation, it appears that PDHA2 is associated with the process of capacitation [1].
  • This is the first report showing that hamster sperm PDHA2 is a testis-specific phosphotyrosine that is associated with the fibrous sheath of hamster spermatozoa [1].
  • An autosomal locus, PDHA2, showing significant cross-hybridization with a PDH E1 alpha cDNA probe, was detected on chromosome 4, in the region q22-q23 [2].
  • This review focuses on our current understanding of the expression and regulation of Pdha-2 during spermatogenesis [3].
  • Pdha-2: a model for studying transcriptional regulation in early spermatocytes [3].

Biological context of PDHA2

  • In this report, we have identified pyruvate dehydrogenase A2 (PDHA2), a constituent of pyruvate dehydrogenase A (PDHA), which is a component of pyruvate dehydrogenase complex that exhibits tyrosine phosphorylation during hamster spermatozoal capacitation [1].
  • A genomic fragment harboring the human gene encoding PDHA-2 has been isolated and approximately 800 nucleotides of the promoter region have been characterized [4].
  • Characterization of the regulatory region of the human testis-specific form of the pyruvate dehydrogenase alpha-subunit (PDHA-2) gene [4].

Anatomical context of PDHA2


Other interactions of PDHA2

  • The gene located on chromosome X (PDHA-1) is expressed in somatic tissues, whereas the second gene (PDHA-2), located on chromosome 4, is expressed only in post-meiotic spermatogenic cells [4].


  1. Activity of Pyruvate Dehydrogenase A (PDHA) in Hamster Spermatozoa Correlates Positively with Hyperactivation and Is Associated with Sperm Capacitation. Kumar, V., Rangaraj, N., Shivaji, S. Biol. Reprod. (2006) [Pubmed]
  2. A testis-specific form of the human pyruvate dehydrogenase E1 alpha subunit is coded for by an intronless gene on chromosome 4. Dahl, H.H., Brown, R.M., Hutchison, W.M., Maragos, C., Brown, G.K. Genomics (1990) [Pubmed]
  3. Pdha-2: a model for studying transcriptional regulation in early spermatocytes. Iannello, R.C., Young, J.C., Kola, I. Mol. Reprod. Dev. (1994) [Pubmed]
  4. Characterization of the regulatory region of the human testis-specific form of the pyruvate dehydrogenase alpha-subunit (PDHA-2) gene. Datta, U., Wexler, I.D., Kerr, D.S., Raz, I., Patel, M.S. Biochim. Biophys. Acta (1999) [Pubmed]
  5. Review: Pdha-2, past and present. Young, J.C., Gould, J.A., Kola, I., Iannello, R.C. J. Exp. Zool. (1998) [Pubmed]
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