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Gene Review:

ATP6V0C - ATPase, H+ transporting, lysosomal 16kDa,...

Homo sapiens

Synonyms: ATP6C, ATP6L, ATPL, V-ATPase 16 kDa proteolipid subunit, V-type proton ATPase 16 kDa proteolipid subunit, ...

Lu, X. et al., Simckes, A.M. et al., Waguespack, S.G. et al., Torigoe, T. et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of ATP6V0C

In this study, ATP6L in a human hepatocellular carcinoma cell line with highly metastatic potential (HCCLM3) was knocked down using DNA vector-based small interfering RNA (siRNA) to suppress the metastasis [1].

High impact information on ATP6V0C

In control, all eight mice had the intrahepatic metastasis and six of eight the pulmonary metastasis, whereas in ATP6L siRNA-treated group, three of eight had the intrahepatic metastasis and only one of eight the pulmonary metastasis [1].
The growth and metastasis of human hepatocellular carcinoma xenografts are inhibited by small interfering RNA targeting to the subunit ATP6L of proton pump [1].
Although cisplatin did not induce ATP6L promoter activity, it altered ATP6L mRNA stability [2].
3. Critical meiotic recombination events further narrowed the putative gene region to a 7.6-cM area, which contains the candidate genes ATP6L and chloride channel 7 (ClCN7) [3].
Chromosomal localization of three vacuolar-H+ -ATPase 16 kDa subunit (ATP6V0C) genes in the murine genome [4].

Biological context of ATP6V0C

This region of Chromosome 17 in mouse is homologous with chromosome 16 in human where the ATP6V0C gene is localized [4].

References

The growth and metastasis of human hepatocellular carcinoma xenografts are inhibited by small interfering RNA targeting to the subunit ATP6L of proton pump. Lu, X., Qin, W., Li, J., Tan, N., Pan, D., Zhang, H., Xie, L., Yao, G., Shu, H., Yao, M., Wan, D., Gu, J., Yang, S. Cancer Res. (2005) [Pubmed]
Enhanced expression of the human vacuolar H+-ATPase c subunit gene (ATP6L) in response to anticancer agents. Torigoe, T., Izumi, H., Ishiguchi, H., Uramoto, H., Murakami, T., Ise, T., Yoshida, Y., Tanabe, M., Nomoto, M., Itoh, H., Kohno, K. J. Biol. Chem. (2002) [Pubmed]
Chloride channel 7 (ClCN7) gene mutations and autosomal dominant osteopetrosis, type II. Waguespack, S.G., Koller, D.L., White, K.E., Fishburn, T., Carn, G., Buckwalter, K.A., Johnson, M., Kocisko, M., Evans, W.E., Foroud, T., Econs, M.J. J. Bone Miner. Res. (2003) [Pubmed]
Chromosomal localization of three vacuolar-H+ -ATPase 16 kDa subunit (ATP6V0C) genes in the murine genome. Simckes, A.M., Swanson, S.K., White, R.A. Cytogenet. Genome Res. (2002) [Pubmed]

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AGOS_AEL074W	Ashbya gossypii ATCC 10895
ATP6V0C	Bos taurus
vha-2	Caenorhabditis elegans
vha-3	Caenorhabditis elegans
vha-1	Caenorhabditis elegans
ATP6V0C	Canis lupus familiaris
atp6v0cb	Danio rerio
atp6v0ca	Danio rerio
Vha16-1	Drosophila melanogaster
Vha16-3	Drosophila melanogaster
ATP6V0C	Gallus gallus
KLLA0E22441g	Kluyveromyces lactis NRRL Y-1140
ATP6V0C	Macaca mulatta
MGG_02466	Magnaporthe oryzae 70-15
Atp6v0c	Mus musculus
NCU01332	Neurospora crassa OR74A
Os01g0962300	Oryza sativa Japonica Group
ATP6V0C	Pan troglodytes
Atp6v0c	Rattus norvegicus
VMA3	Saccharomyces cerevisiae S288c
vma3	Schizosaccharomyces pombe 972h-
atp6v0c	Xenopus (Silurana) tropicalis

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