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Gene Review:

Timm23 - translocase of inner mitochondrial...

Mus musculus

Synonyms: Mitochondrial import inner membrane translocase subunit Tim23, Tim23

Sun, Y. et al., Joseph, A.M. et al.

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High impact information on Timm23

In rho(-) cells, Tom20 and Tim23 protein levels were reduced by 25% and 59%, whereas mtHSP70 was induced by twofold relative to control cells [1].
Hormonal regulation of mitochondrial Tim23 gene expression in the mouse mammary gland [2].
In situ hybridization showed that mammary epithelial cells expressed Tim23 mRNA during pregnancy [2].
In adreno-ovariectomized mice, the administration of cortisol increased Tim23 mRNA 2-fold but with progesterone, the stimulatory action of cortisol was no longer observed [2].
Tim23, a mitochondrial inner membrane protein, is essential for cell viability [2].

Analytical, diagnostic and therapeutic context of Timm23

On day 13 of pregnancy, Tim23 mRNA increased 2.7-fold between 8 and 16 h after ovariectomy but this increase was cancelled out by the simultaneous operation of adrenalectomy [2].
In order to examine the hormonal regulation of the Tim23 gene expression at lactogenesis, the quantity of Tim23 mRNA in the mammary gland was determined by the competitive RT-PCR [2].

References

Compensatory responses of protein import and transcription factor expression in mitochondrial DNA defects. Joseph, A.M., Rungi, A.A., Robinson, B.H., Hood, D.A. Am. J. Physiol., Cell Physiol. (2004) [Pubmed]
Hormonal regulation of mitochondrial Tim23 gene expression in the mouse mammary gland. Sun, Y., Kuraishi, T., Aoki, F., Sakai, S. Mol. Cell. Endocrinol. (2001) [Pubmed]

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AgaP_AGAP010210	Anopheles gambiae str. PEST
TIMM23	Bos taurus
LOC486776	Canis lupus familiaris
timm23	Danio rerio
CG40042	Drosophila melanogaster
TIMM23	Gallus gallus
TIMM23	Homo sapiens
TIMM23	Macaca mulatta
TIMM23	Pan troglodytes
Timm23	Rattus norvegicus
LOC100362432	Rattus norvegicus
Timm23b	Rattus norvegicus
timm23	Xenopus (Silurana) tropicalis

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