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Gene Review

Immt  -  inner membrane protein, mitochondrial

Mus musculus

Synonyms: 1700082C19Rik, D830041H16Rik, HMP, MICOS complex subunit Mic60, Mic60, ...
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Disease relevance of Immt

  • Mitochondrial-inner-membrane vesicles, isolated from Ehrlich ascites carcinoma cells by titration with detergents, accumulated L-glutamine by a very efficient transport system [1].
  • In this study the encephalitogenic epitope P87 - 99 of myelin basic protein has been prepared in the retro-inverso form to examine its biological activity in a murine model of multiple sclerosis [2].
  • Species-specific monoclonal antibodies (MAbs) were developed against Mycoplasma agalactiae reference strain PG2 and French isolate P89 to study the in vitro expression of surface epitopes and to probe the antigenic profiles of 245 field isolates originating from 10 different countries [3].

High impact information on Immt


Biological context of Immt


Anatomical context of Immt


Associations of Immt with chemical compounds

  • Administration of nifedipine to mice over a period of six months caused a significant (p < 0.05) decrease in neutrophilic functions viz superoxide generation, coupled to NADPH oxidase activity as well as NADPH production by HMP shunt [11].


  1. Glutamine transport by vesicles isolated from tumour-cell mitochondrial inner membrane. Molina, M., Segura, J.A., Aledo, J.C., Medina, M.A., Núnez de Castro, I., Márquez, J. Biochem. J. (1995) [Pubmed]
  2. Inhibition of experimental autoimmune encephalomyelitis in SJL mice by oral administration of retro-inverso derivative of encephalitogenic epitope P87-99. Marino, M., Ippolito, A., Fassina, G. Eur. J. Immunol. (1999) [Pubmed]
  3. Variable expression and geographic distribution of Mycoplasma agalactiae surface epitopes demonstrated with monoclonal antibodies. Bergonier, D., De Simone, F., Russo, P., Solsona, M., Lambert, M., Poumarat, F. FEMS Microbiol. Lett. (1996) [Pubmed]
  4. The presequences of two imported mitochondrial proteins contain information for intracellular and intramitochondrial sorting. van Loon, A.P., Brändli, A.W., Schatz, G. Cell (1986) [Pubmed]
  5. Characterization of mammalian translocase of inner mitochondrial membrane (Tim44) isolated from diabetic newborn mouse kidney. Wada, J., Kanwar, Y.S. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  6. Hormonal regulation of mitochondrial Tim23 gene expression in the mouse mammary gland. Sun, Y., Kuraishi, T., Aoki, F., Sakai, S. Mol. Cell. Endocrinol. (2001) [Pubmed]
  7. Regulatory aspects of cholesterol metabolism in cells with different degrees of replication. Rao, K.N. Toxicologic pathology. (1986) [Pubmed]
  8. Effects of the presence, absence, and overexpression of uncoupling protein-3 on adiposity and fuel metabolism in congenic mice. Costford, S.R., Chaudhry, S.N., Salkhordeh, M., Harper, M.E. Am. J. Physiol. Endocrinol. Metab. (2006) [Pubmed]
  9. Tissue cyst tropism in Toxoplasma gondii: a comparison of tissue cyst formation in organs of cats, and rodents fed oocysts. Dubey, J.P. Parasitology (1997) [Pubmed]
  10. Androgenic regulation of glycolytic and HMP pathway in epididymis and vas deferens of rhesus monkey. Gupta, G., Srivastava, A., Setty, B.S. Indian J. Exp. Biol. (1993) [Pubmed]
  11. Effect of nifedipine administration on the functional capacity of neutrophils. Kaul, N., Andrabi, K.I., Ganguly, N.K., Wahi, P.L. Mol. Cell. Biochem. (1993) [Pubmed]
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