Disease relevance of Celsr2

• Cutaneous geotrichosis in the red flamingo (Phoenicopterus ruber) [1].

High impact information on Celsr2

• Dvl1 had a broad expression, reminiscent of that of Celsr2, and may be involved in neural maintenance [2].
• Celsr2 is mapped to a distal region of the mouse chromosome 3 [3].
• The Celsr2 protein was distributed at intercellular boundaries in the whisker and on processes of neuronal cells such as hippocampal pyramidal cells, Purkinje cells, and olfactory neurons [3].
• However, the canvas of Ankrd6 expression does not match closely that of the three mouse Flamingo homologs, Celsr1-3 (Tissir et al., 2002) [4].
• Celsr1 and Celsr2 expression is observed during gastrulation and within the developing nervous system [5].

Biological context of Celsr2

• These three genes represent vertebrate homologues of flamingo/starry night, recently identified as an essential component of the Drosophila planar cell polarity pathway and for the correct formation of dendritic fields within the Drosophila peripheral nervous system [5].
• The flamingo-related mouse Celsr family (Celsr1-3) genes exhibit distinct patterns of expression during embryonic development [5].

Associations of Celsr2 with chemical compounds

• Mouse Flamingo1/Celsr2 relates neuronal reorganization of the hypertrophic dentate granule cells after kainate injection [6].

References