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Gene Review

Celsr2  -  cadherin, EGF LAG seven-pass G-type...

Mus musculus

Synonyms: Cadherin EGF LAG seven-pass G-type receptor 2, EGFL2, Flamingo homolog, Flamingo1, flamingo, ...
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Disease relevance of Celsr2


High impact information on Celsr2

  • Dvl1 had a broad expression, reminiscent of that of Celsr2, and may be involved in neural maintenance [2].
  • Celsr2 is mapped to a distal region of the mouse chromosome 3 [3].
  • The Celsr2 protein was distributed at intercellular boundaries in the whisker and on processes of neuronal cells such as hippocampal pyramidal cells, Purkinje cells, and olfactory neurons [3].
  • However, the canvas of Ankrd6 expression does not match closely that of the three mouse Flamingo homologs, Celsr1-3 (Tissir et al., 2002) [4].
  • Celsr1 and Celsr2 expression is observed during gastrulation and within the developing nervous system [5].

Biological context of Celsr2


Associations of Celsr2 with chemical compounds

  • Mouse Flamingo1/Celsr2 relates neuronal reorganization of the hypertrophic dentate granule cells after kainate injection [6].


  1. Cutaneous geotrichosis in the red flamingo (Phoenicopterus ruber). Spanoghe, L., Devos, A., Viaene, N. Sabouraudia. (1976) [Pubmed]
  2. Expression of planar cell polarity genes during development of the mouse CNS. Tissir, F., Goffinet, A.M. Eur. J. Neurosci. (2006) [Pubmed]
  3. Differential expression of the seven-pass transmembrane cadherin genes Celsr1-3 and distribution of the Celsr2 protein during mouse development. Shima, Y., Copeland, N.G., Gilbert, D.J., Jenkins, N.A., Chisaka, O., Takeichi, M., Uemura, T. Dev. Dyn. (2002) [Pubmed]
  4. Expression of the ankyrin repeat domain 6 gene (Ankrd6) during mouse brain development. Tissir, F., Bar, I., Goffinet, A.M., Lambert De Rouvroit, C. Dev. Dyn. (2002) [Pubmed]
  5. The flamingo-related mouse Celsr family (Celsr1-3) genes exhibit distinct patterns of expression during embryonic development. Formstone, C.J., Little, P.F. Mech. Dev. (2001) [Pubmed]
  6. Mouse Flamingo1/Celsr2 relates neuronal reorganization of the hypertrophic dentate granule cells after kainate injection. Hirai, H., Suzuki, F., Kurokawa, K., Mitsuya, K., Matsuda, M. Brain Res. (2003) [Pubmed]
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