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Gene Review

CELSR2  -  cadherin, EGF LAG seven-pass G-type...

Homo sapiens

Synonyms: CDHF10, Cadherin EGF LAG seven-pass G-type receptor 2, Cadherin family member 10, EGF-like protein 2, EGFL2, ...
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Disease relevance of CELSR2


High impact information on CELSR2

  • Tissue morphogenesis during development is dependent on activities of the cadherin family of cell-cell adhesion proteins that includes classical cadherins, protocadherins, and atypical cadherins (Fat, Dachsous, and Flamingo) [5].
  • We propose that Wnt11, by interacting with Frizzled 7 and Flamingo, modulates local cell contact persistence to coordinate cell movements during gastrulation [6].
  • RESULTS: Celsr2 was down-regulated in one cell line and in 7% of breast cancers [7].
  • Using methylated CpG island amplification (MCA)/representational difference analysis (RDA), we identified four CpG islands in neurotrophin tyrosine kinase receptor type 2 (NTRK2), Protocadherine Flamingo1 and MFPC (Methylated Fragments in Prostate Cancer) 7 and 8 [8].
  • A comparison with tandemly repeated DNA sequences in other avian species showed that several of these conserved elements were also present at similar locations within the 184-bp repeat of the Chilean flamingo (Phoenicopterus chilensis), suggesting a great antiquity of the repeat [9].

Biological context of CELSR2


Anatomical context of CELSR2

  • Because GPCRs are regulated by phosphorylation, the hypothesis that phthalate exposure induces the phosphorylation of celsr2 was tested by examining phosphorylation in celsr2-transfected HeLa cells treated with MEHP [10].
  • CONCLUSIONS: Flamingo stents are effective for palliation of malignant dysphagia, but the large diameter stent seems to be associated with more complications involving the esophagus than the small diameter stent [11].
  • At a mean follow-up of 52.4 months, all patients were free of symptoms and flamingo views confirmed successful arthrodesis with no residual instability of the pubic symphysis [12].
  • DESIGN: Evaluation of 338 prospectively followed patients with dysphagia from obstructing esophageal or gastric cardia cancer who were treated with an Ultraflex stent (n = 153), a Gianturco Z-stent (n = 89), or a Flamingo Wallstent (n = 96) of either a small diameter (n = 265) or a large diameter (n = 73) during the period 1996 to 2004 [13].
  • Within 2 h of a 1-g/kg mono-(2-ethylhexyl) phthalate (MEHP) exposure, in vivo Sertoli cell celsr2 localization was altered; celsr2 immunostaining became concentrated in the basal aspect of Sertoli cells, and then a diffuse pattern emerged [10].

Associations of CELSR2 with chemical compounds


Regulatory relationships of CELSR2


Other interactions of CELSR2


Analytical, diagnostic and therapeutic context of CELSR2

  • Physical fitness included health-related items (step test, PWC170, the sit and reach, sit-ups and leg lifts, flexed arm hang) and motor performance items (standing long jump, vertical jump, arm pull strength, flamingo stand, shuttle run, plate tapping) [17].
  • Moreover, minor complications, particularly pain, were associated with prior radiation and/or chemotherapy in patients with a large- or a small-diameter Gianturco Z-stent (HR 4.27, 95% CI 1.44-12.71) but not in those with an Ultraflex stent or a Flamingo Wallstent [13].
  • These two patients had an esophagocutaneous fistula following laryngectomy and a Flamingo Wall stent was used [18].
  • Flamingo forceps for use in microscopic antrostomy [19].
  • CONCLUSION: Flamingo stents provide an effective and safe choice of palliative therapy in inoperable malignant esophagogastric strictures [20].


  1. A randomised prospective comparison of the Flamingo Wallstent and Ultraflex stent for palliation of dysphagia associated with lower third oesophageal carcinoma. Sabharwal, T., Hamady, M.S., Chui, S., Atkinson, S., Mason, R., Adam, A. Gut (2003) [Pubmed]
  2. Palliative treatment of inoperable malignant esophageal strictures with metal stents: one center's experience with four different stents. Rozanes, I., Poyanli, A., Acunaş, B. European journal of radiology. (2002) [Pubmed]
  3. Amyloidosis, hemochromatosis, and atherosclerosis in a roseate flamingo (Phoenicopterus ruber). Brayton, C. Ann. N. Y. Acad. Sci. (1992) [Pubmed]
  4. Cestodiasis with intestinal diverticulosis in a lesser flamingo (Phoeniconaias minor). Poynton, S.L., Mukherjee, G., Strandberg, J.D. J. Zoo Wildl. Med. (2000) [Pubmed]
  5. Cadherins in development: cell adhesion, sorting, and tissue morphogenesis. Halbleib, J.M., Nelson, W.J. Genes Dev. (2006) [Pubmed]
  6. Wnt11 controls cell contact persistence by local accumulation of Frizzled 7 at the plasma membrane. Witzel, S., Zimyanin, V., Carreira-Barbosa, F., Tada, M., Heisenberg, C.P. J. Cell Biol. (2006) [Pubmed]
  7. Aberrant expression of novel and previously described cell membrane markers in human breast cancer cell lines and tumors. Huang, H., Groth, J., Sossey-Alaoui, K., Hawthorn, L., Beall, S., Geradts, J. Clin. Cancer Res. (2005) [Pubmed]
  8. Identification of differentially methylated CpG islands in prostate cancer. Yamada, Y., Toyota, M., Hirokawa, Y., Suzuki, H., Takagi, A., Matsuzaki, T., Sugimura, Y., Yatani, R., Shiraishi, T., Watanabe, M. Int. J. Cancer (2004) [Pubmed]
  9. Highly repeated DNA sequences in birds: the structure and evolution of an abundant, tandemly repeated 190-bp DNA fragment in parrots. Madsen, C.S., de Kloet, D.H., Brooks, J.E., de Kloet, S.R. Genomics (1992) [Pubmed]
  10. Mono-(2-ethylhexyl) phthalate rapidly increases celsr2 protein phosphorylation in HeLa cells via protein kinase C and casein kinase 1. Lahousse, S.A., Beall, S.A., Johnson, K.J. Toxicol. Sci. (2006) [Pubmed]
  11. A new design metal stent (Flamingo stent) for palliation of malignant dysphagia: a prospective study. The Rotterdam Esophageal Tumor Study Group. Siersema, P.D., Hop, W.C., van Blankenstein, M., Dees, J. Gastrointest. Endosc. (2000) [Pubmed]
  12. Osteitis pubis and instability of the pubic symphysis. When nonoperative measures fail. Williams, P.R., Thomas, D.P., Downes, E.M. The American journal of sports medicine. (2000) [Pubmed]
  13. Effect of stent size on complications and recurrent dysphagia in patients with esophageal or gastric cardia cancer. Verschuur, E.M., Steyerberg, E.W., Kuipers, E.J., Siersema, P.D. Gastrointest. Endosc. (2007) [Pubmed]
  14. Body composition and physical fitness of undernourished South African rural primary school children. Monyeki, M.A., Koppes, L.L., Kemper, H.C., Monyeki, K.D., Toriola, A.L., Pienaar, A.E., Twisk, J.W. European journal of clinical nutrition. (2005) [Pubmed]
  15. Identification and characterization of rat Ankrd6 gene in silico. Katoh, M., Katoh, M. Int. J. Mol. Med. (2005) [Pubmed]
  16. Identification of tyrosine kinases overexpressed in head and neck cancer. Lin, H.S., Berry, G.J., Fee, W.E., Terris, D.J., Sun, Z. Arch. Otolaryngol. Head Neck Surg. (2004) [Pubmed]
  17. Fatness and physical fitness of girls 7 to 17 years. Malina, R.M., Beunen, G.P., Classens, A.L., Lefevre, J., Vanden Eynde, B.V., Renson, R., Vanreusel, B., Simons, J. Obes. Res. (1995) [Pubmed]
  18. Endoprosthesis implantation at the pharyngo-esophageal level: Problems, limitations and challenges. Eleftheriadis, E., Kotzampassi, K. World J. Gastroenterol. (2006) [Pubmed]
  19. Flamingo forceps for use in microscopic antrostomy. Dixon, H.S. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery. (1981) [Pubmed]
  20. Palliative treatment of inoperable malignant esophageal strictures with conically shaped covered self-expanding stents. Poyanli, A., Sencer, S., Rozanes, I., Acunaş, B. Acta radiologica (Stockholm, Sweden : 1987) (2001) [Pubmed]
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