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Gene Review:

RAB24 - RAB24, member RAS oncogene family

Homo sapiens

Synonyms: Ras-related protein Rab-24

Erdman, R.A. et al., Wu, M. et al., Olkkonen, V.M. et al., Munafó, D.B. et al., Jacobsen, M. et al.

Jacobsen, Repsilber, Gutschmidt, Neher, Feldmann, Mollenkopf, Ziegler, Kaufmann,

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High impact information on RAB24

Rab24 is an atypical member of the Rab GTPase family. Deficient GTPase activity, GDP dissociation inhibitor interaction, and prenylation of Rab24 expressed in cultured cells [1].
2) Posttranslational geranylgeranylation of Rab24, determined by metabolic labeling or detergent partitioning assays, is inefficient when compared with other Rabs ending with the common CXC and CC carboxyl-terminal motifs [1].
3) Most of the Rab24 in the cytoplasmic compartment of cultured cells is not associated with Rab GDP dissociation inhibitors [1].
The function of Rab24 is currently unknown, but other members of the Rab GTPase family are known to participate in various protein trafficking pathways [1].
These findings indicate that, if Rab24 functions in vesicular transport processes, it may operate through a novel mechanism that does not depend on GTP hydrolysis or GDP dissociation inhibitor-mediated recycling [1].

Biological context of RAB24

These PCR fragments have not been used with cDNA library screening and PCR-based techniques to clone the cDNAs encoding three of these proteins, rab12, rab22, and rab24 [2].
Furthermore, Rab24 colocalized with LC3, a mammalian homolog of the yeast protein Apg8/Aut7, an essential gene for autophagy [3].

Anatomical context of RAB24

RAB24 (D123I) can trigger the accumulation of intracellular inclusions, with small quantities of intranuclear inclusions in some cells [4].
Human RAB24, interestingly and predominantly distributed in the nuclei of COS-7 cells, is colocalized with cyclophilin A and GABARAP [4].
Interestingly, RAB24 is predominantly localized in the nuclei of COS-7 cells, which is different from previous reports using other cell lines [4].
1) Based on [(32)P]orthophosphate labeling of protein-bound nucleotide, Rab24 exists predominantly in the GTP state when expressed in cultured cells [1].
Finally, rab24 was found in the endoplasmic reticulum/cis-Golgi region and on late endosomal structures [2].

Other interactions of RAB24

Comparison revealed significant differences in the expression of genes for Rab13, Rab24, and Rab33A [5].

References

Rab24 is an atypical member of the Rab GTPase family. Deficient GTPase activity, GDP dissociation inhibitor interaction, and prenylation of Rab24 expressed in cultured cells. Erdman, R.A., Shellenberger, K.E., Overmeyer, J.H., Maltese, W.A. J. Biol. Chem. (2000) [Pubmed]
Molecular cloning and subcellular localization of three GTP-binding proteins of the rab subfamily. Olkkonen, V.M., Dupree, P., Killisch, I., Lütcke, A., Zerial, M., Simons, K. J. Cell. Sci. (1993) [Pubmed]
Induction of autophagy causes dramatic changes in the subcellular distribution of GFP-Rab24. Munafó, D.B., Colombo, M.I. Traffic (2002) [Pubmed]
Human RAB24, interestingly and predominantly distributed in the nuclei of COS-7 cells, is colocalized with cyclophilin A and GABARAP. Wu, M., Yin, G., Zhao, X., Ji, C., Gu, S., Tang, R., Dong, H., Xie, Y., Mao, Y. Int. J. Mol. Med. (2006) [Pubmed]
Ras-associated small GTPase 33A, a novel T cell factor, is down-regulated in patients with tuberculosis. Jacobsen, M., Repsilber, D., Gutschmidt, A., Neher, A., Feldmann, K., Mollenkopf, H.J., Ziegler, A., Kaufmann, S.H. J. Infect. Dis. (2005) [Pubmed]

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