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Gene Review

RAB13  -  RAB13, member RAS oncogene family

Homo sapiens

Synonyms: Cell growth-inhibiting gene 4 protein, GIG4, Ras-related protein Rab-13
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High impact information on RAB13


Biological context of RAB13


Anatomical context of RAB13


Physical interactions of RAB13


Co-localisations of RAB13

  • Double immunolabelings showed that a fraction of endocytosed occludin was colocalized with Rab13 in MTD-1A cells [5].

Other interactions of RAB13

  • Rab13 mediates the continuous endocytic recycling of occludin to the cell surface [5].
  • This report demonstrates that Rab8 and Rab13 proteins are isoprenylated in vivo and geranylgeranylated in vitro [7].
  • We rename MICAL-L2 as JRAB (junctional Rab13-binding protein) [4].
  • Interestingly, activation of PKA abrogates the inhibitory effect of Rab13 on the recruitment of vasodilator-stimulated phosphoprotein, ZO-1, and claudin1 to cell-cell junctions [1].
  • Comparison revealed significant differences in the expression of genes for Rab13, Rab24, and Rab33A [8].


  1. Rab13 regulates PKA signaling during tight junction assembly. Köhler, K., Louvard, D., Zahraoui, A. J. Cell Biol. (2004) [Pubmed]
  2. A small rab GTPase is distributed in cytoplasmic vesicles in non polarized cells but colocalizes with the tight junction marker ZO-1 in polarized epithelial cells. Zahraoui, A., Joberty, G., Arpin, M., Fontaine, J.J., Hellio, R., Tavitian, A., Louvard, D. J. Cell Biol. (1994) [Pubmed]
  3. Assignment of the Rab13 gene (RAB13) to human chromosome band 12q13 by in situ hybridization. Leek, J.P., Hamlin, P.J., Wilton, J., Lench, N.J. Cytogenet. Cell Genet. (1997) [Pubmed]
  4. JRAB/MICAL-L2 Is a Junctional Rab13-binding Protein Mediating the Endocytic Recycling of Occludin. Terai, T., Nishimura, N., Kanda, I., Yasui, N., Sasaki, T. Mol. Biol. Cell (2006) [Pubmed]
  5. Rab13 mediates the continuous endocytic recycling of occludin to the cell surface. Morimoto, S., Nishimura, N., Terai, T., Manabe, S., Yamamoto, Y., Shinahara, W., Miyake, H., Tashiro, S., Shimada, M., Sasaki, T. J. Biol. Chem. (2005) [Pubmed]
  6. The rod cGMP phosphodiesterase delta subunit dissociates the small GTPase Rab13 from membranes. Marzesco, A.M., Galli, T., Louvard, D., Zahraoui, A. J. Biol. Chem. (1998) [Pubmed]
  7. Isoprenylation of Rab proteins possessing a C-terminal CaaX motif. Joberty, G., Tavitian, A., Zahraoui, A. FEBS Lett. (1993) [Pubmed]
  8. Ras-associated small GTPase 33A, a novel T cell factor, is down-regulated in patients with tuberculosis. Jacobsen, M., Repsilber, D., Gutschmidt, A., Neher, A., Feldmann, K., Mollenkopf, H.J., Ziegler, A., Kaufmann, S.H. J. Infect. Dis. (2005) [Pubmed]
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