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Gene Review:

P69B - subtilisin-like protease

Solanum lycopersicum

Tornero, P. et al., Jordá, L. et al., Jordá, L. et al., Tian, M. et al.

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Disease relevance of P69B

By using biochemical, immunological, and molecular strategies we have identified and cloned a cDNA encoding a protease from tomato (Lycopersicon esculentum) plants (P69B) that is part of a proteolytic system activated in the plant as a result of infection with citrus exocortis viroid [1].
P69A and P69D are expressed constitutively, but with different expression profiles during development, whereas the P69B and P69C genes show expression following infection with Pseudomonas syringae and are also up-regulated by salicylic acid [2].

High impact information on P69B

The 745-residue amino acid sequence of P69B begins with a cleavable signal peptide, contains a prodomain and a 631-residue mature domain which is homologous to the catalytic modules of bacterial subtilisins and eukaryotic Kex2-like proteases [1].
Within the catalytic domain, the essential Asp, His, and Ser residues that conform the catalytic triad of this family of proteases are conserved in P69B [1].
Among these, EPI1 and EPI10 bind and inhibit the pathogenesis-related (PR) P69B subtilisin-like serine protease of tomato [3].
Local and systemic induction of two defense-related subtilisin-like protease promoters in transgenic Arabidopsis plants. Luciferin induction of PR gene expression [4].

References

Identification of a new pathogen-induced member of the subtilisin-like processing protease family from plants. Tornero, P., Conejero, V., Vera, P. J. Biol. Chem. (1997) [Pubmed]
A genomic cluster containing four differentially regulated subtilisin-like processing protease genes is in tomato plants. Jordá, L., Coego, A., Conejero, V., Vera, P. J. Biol. Chem. (1999) [Pubmed]
A Phytophthora infestans Cystatin-Like Protein Targets a Novel Tomato Papain-Like Apoplastic Protease. Tian, M., Win, J., Song, J., van der Hoorn, R., van der Knaap, E., Kamoun, S. Plant Physiol. (2007) [Pubmed]
Local and systemic induction of two defense-related subtilisin-like protease promoters in transgenic Arabidopsis plants. Luciferin induction of PR gene expression. Jordá, L., Vera, P. Plant Physiol. (2000) [Pubmed]

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