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Gene Review:

dntt - deoxynucleotidyltransferase, terminal

Danio rerio

Synonyms: SO:0000704

Bever, M.M. et al., Uchida, D. et al., Uchida, D. et al., Daly, F.J. et al., Bahadori, R. et al.

Uchida, Yamashita, Kitano, Iguchi,

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High impact information on TdT

The percentage of terminal-deoxynucleotidyl-transferase-mediated dUTP nick-end labelling (TUNEL)-positive apoptotic oocytes in the gonads of presumptive males was approximately eight- to 12-fold higher than in genetic all-females [1].
Terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling (TUNEL)-positive oocytes of early diplotene and perinucleolar stages in fadrozole-treated genetic females (1000 microg g(-1) diet(-1)) were observed at 15-40 days post-hatching during sex-reversal [2].
Two independent measures, TdT-mediated dUTP-biotin nick end label (TUNEL) and transmission electron microscopy, indicate that the pyknotic cells in the mutant retinae are apoptotic [3].
Using in situ terminal deoxynucleotidyl transferase (TdT)-mediated dUTP nick-end labeling (TUNEL) to detect apoptotic cells, we show that developing Xenopus and zebrafish ears have apoptotic cells in the eighth cranial ganglia, the developing sensory patches, and in various positions in the otocyst wall [4].

Analytical, diagnostic and therapeutic context of TdT

Apoptotic cells were visualized by TdT-mediated dUTP nick-end labeling (TUNEL) staining [5].

References

Oocyte apoptosis during the transition from ovary-like tissue to testes during sex differentiation of juvenile zebrafish. Uchida, D., Yamashita, M., Kitano, T., Iguchi, T. J. Exp. Biol. (2002) [Pubmed]
An aromatase inhibitor or high water temperature induce oocyte apoptosis and depletion of P450 aromatase activity in the gonads of genetic female zebrafish during sex-reversal. Uchida, D., Yamashita, M., Kitano, T., Iguchi, T. Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. (2004) [Pubmed]
Inherited retinal degeneration and apoptosis in mutant zebrafish. Daly, F.J., Sandell, J.H. Anat. Rec. (2000) [Pubmed]
Ventromedial focus of cell death is absent during development of Xenopus and zebrafish inner ears. Bever, M.M., Fekete, D.M. J. Neurocytol. (1999) [Pubmed]
The Zebrafish fade out Mutant: A Novel Genetic Model for Hermansky-Pudlak Syndrome. Bahadori, R., Rinner, O., Schonthaler, H.B., Biehlmaier, O., Makhankov, Y.V., Rao, P., Jagadeeswaran, P., Neuhauss, S.C. Invest. Ophthalmol. Vis. Sci. (2006) [Pubmed]

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DNTT	Bos taurus
DNTT	Canis lupus familiaris
DNTT	Gallus gallus
DNTT	Homo sapiens
DNTT	Macaca mulatta
Dntt	Mus musculus
DNTT	Pan troglodytes
Dntt	Rattus norvegicus
dntt	Xenopus (Silurana) tropicalis

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