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Gene Review

DNTT  -  DNA nucleotidylexotransferase

Bos taurus

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Disease relevance of DNTT


High impact information on DNTT


Biological context of DNTT

  • The specificity of dTTP cross-linking at the substrate binding site in TdT is demonstrated by the competitive inhibition of the cross-linking reaction by other deoxynucleoside triphosphates, and ATP and its analogues, requiring concentrations consistent with their kinetic constants [9].
  • Further proteolytic digestion of the tryptic peptide-dTTP complex, using V8 protease, yielded a smaller peptide, and its analysis narrowed the substrate binding domain to 14 amino acids corresponding to residues 224-237 in the primary amino acid sequence of TdT [9].
  • The bovine TdT cDNA clone contains an open reading frame coding for 520 amino acids, Mr 59,678 [10].
  • A 58-kDa monomer of terminal transferase was isolated from calf thymus using a monoclonal antibody affinity column [11].
  • The phosphorylation and phosphonylation of the 3'-hydroxyl of oligodeoxynucleotide 3'-termini (oligodeoxynucleotidyl kinase activity) catalyzed by calf thymus terminal deoxynucleotidyl transferase (TDT) are discussed [12].

Anatomical context of DNTT


Associations of DNTT with chemical compounds


Other interactions of DNTT


Analytical, diagnostic and therapeutic context of DNTT


  1. Purification of terminal deoxynucleotidyltransferase by oligonucleotide affinity chromatography. Okamura, S., Crane, F., Messner, H.A., Mak, T.W. J. Biol. Chem. (1978) [Pubmed]
  2. Stereospecificity of human DNA polymerases alpha, beta, gamma, delta and epsilon, HIV-reverse transcriptase, HSV-1 DNA polymerase, calf thymus terminal transferase and Escherichia coli DNA polymerase I in recognizing D- and L-thymidine 5'-triphosphate as substrate. Focher, F., Maga, G., Bendiscioli, A., Capobianco, M., Colonna, F., Garbesi, A., Spadari, S. Nucleic Acids Res. (1995) [Pubmed]
  3. Terminal nucleotidyl transferase activity of recombinant Flaviviridae RNA-dependent RNA polymerases: implication for viral RNA synthesis. Ranjith-Kumar, C.T., Gajewski, J., Gutshall, L., Maley, D., Sarisky, R.T., Kao, C.C. J. Virol. (2001) [Pubmed]
  4. Terminal transferase-like activity in human melanoma cells. Gregg, K., Mansbridge, J.N. Aust. J. Biol. Sci. (1979) [Pubmed]
  5. Well-defined insoluble primers for the enzymatic synthesis of oligo- and polynucleotides. Köster, H., Albersmeyer, K., Skroch, D. Hoppe-Seyler's Z. Physiol. Chem. (1978) [Pubmed]
  6. Isoforms of terminal deoxynucleotidyltransferase: developmental aspects and function. Thai, T.H., Kearney, J.F. Adv. Immunol. (2005) [Pubmed]
  7. Molecular cloning of human terminal deoxynucleotidyltransferase. Peterson, R.C., Cheung, L.C., Mattaliano, R.J., Chang, L.M., Bollum, F.J. Proc. Natl. Acad. Sci. U.S.A. (1984) [Pubmed]
  8. Doxorubicin-induced apoptosis in endothelial cells and cardiomyocytes is ameliorated by nitrone spin traps and ebselen. Role of reactive oxygen and nitrogen species. Kotamraju, S., Konorev, E.A., Joseph, J., Kalyanaraman, B. J. Biol. Chem. (2000) [Pubmed]
  9. Biochemistry of terminal deoxynucleotidyltransferase. Affinity labeling and identification of the deoxynucleoside triphosphate binding domain of terminal deoxynucleotidyltransferase. Pandey, V., Modak, M.J. J. Biol. Chem. (1988) [Pubmed]
  10. Isolation and characterization of bovine and mouse terminal deoxynucleotidyltransferase cDNAs expressible in mammalian cells. Koiwai, O., Yokota, T., Kageyama, T., Hirose, T., Yoshida, S., Arai, K. Nucleic Acids Res. (1986) [Pubmed]
  11. Interaction of terminal transferase with single-stranded DNA. Robbins, D.J., Barkley, M.D., Coleman, M.S. J. Biol. Chem. (1987) [Pubmed]
  12. Terminal deoxynucleotidyl transferase. catalysis of DNA (oligodeoxynucleotide) phosphorylation. Krayevsky, A.A., Victorova, L.S., Arzumanov, A.A., Jasko, M.V. Pharmacol. Ther. (2000) [Pubmed]
  13. Analysis of human terminal deoxynucleotidyl transferase cDNA expressible in mammalian cells. Koiwai, O., Kaneda, T., Morishita, R. Biochem. Biophys. Res. Commun. (1987) [Pubmed]
  14. Bovine herpesvirus 1 can infect CD4(+) T lymphocytes and induce programmed cell death during acute infection of cattle. Winkler, M.T., Doster, A., Jones, C. J. Virol. (1999) [Pubmed]
  15. Biosynthesis of murine terminal deoxynucleotidyltransferase. Silverstone, A., Sun, L., Witte, O.N., Baltimore, D. J. Biol. Chem. (1980) [Pubmed]
  16. Enzymatic synthesis of polymers containing nicotinamide mononucleotide. Liu, R., Orgel, L.E. Nucleic Acids Res. (1995) [Pubmed]
  17. 2'-Deoxy-6-thioguanosine 5'-triphosphate as a substrate for purified human DNA polymerases and calf thymus terminal deoxynucleotidyltransferase in vitro. Ling, Y.H., Nelson, J.A., Cheng, Y.C., Anderson, R.S., Beattie, K.L. Mol. Pharmacol. (1991) [Pubmed]
  18. Infection of cattle with a bovine herpesvirus 1 strain that contains a mutation in the latency-related gene leads to increased apoptosis in trigeminal ganglia during the transition from acute infection to latency. Lovato, L., Inman, M., Henderson, G., Doster, A., Jones, C. J. Virol. (2003) [Pubmed]
  19. Photoaffinity labeling of terminal deoxynucleotidyl transferase. 2. Identification of peptides in the nucleotide binding domain. Evans, R.K., Beach, C.M., Coleman, M.S. Biochemistry (1989) [Pubmed]
  20. Cell-free translation of the messenger RNA for calf terminal deoxynucleotidyltransferase. Wolf, S.C., Kourides, I.A., Good, R.A., Silverstone, A.E. J. Biol. Chem. (1982) [Pubmed]
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