Gene Review:
Dntt - deoxynucleotidyltransferase, terminal
Mus musculus
Synonyms:
BB160593, DNA nucleotidylexotransferase, TDT, Tdt, Terminal addition enzyme, ...
- Cloning of terminal transferase cDNA by antibody screening. Landau, N.R., St John, T.P., Weissman, I.L., Wolf, S.C., Silverstone, A.E., Baltimore, D. Proc. Natl. Acad. Sci. U.S.A. (1984)
- Comparison of the two murine terminal [corrected] deoxynucleotidyltransferase terminal isoforms. A 20-amino acid insertion in the highly conserved carboxyl-terminal region modifies the thermosensitivity but not the catalytic activity. Boulé, J.B., Rougeon, F., Papanicolaou, C. J. Biol. Chem. (2000)
- Terminal deoxynucleotidyltransferase deficiency decreases autoimmune disease in diabetes-prone nonobese diabetic mice and lupus-prone MRL-Fas(lpr) mice. Robey, I.F., Peterson, M., Horwitz, M.S., Kono, D.H., Stratmann, T., Theofilopoulos, A.N., Sarvetnick, N., Teyton, L., Feeney, A.J. J. Immunol. (2004)
- Isolation and characterization of bovine and mouse terminal deoxynucleotidyltransferase cDNAs expressible in mammalian cells. Koiwai, O., Yokota, T., Kageyama, T., Hirose, T., Yoshida, S., Arai, K. Nucleic Acids Res. (1986)
- Yersinia-induced apoptosis in vivo aids in the establishment of a systemic infection of mice. Monack, D.M., Mecsas, J., Bouley, D., Falkow, S. J. Exp. Med. (1998)
- Dynamic assembly of silent chromatin during thymocyte maturation. Su, R.C., Brown, K.E., Saaber, S., Fisher, A.G., Merkenschlager, M., Smale, S.T. Nat. Genet. (2004)
- The "initiator" as a transcription control element. Smale, S.T., Baltimore, D. Cell (1989)
- Deficiency in cells expressing terminal transferase in autoimmune (motheaten) mice. Landreth, K.S., McCoy, K., Clagett, J., Bollum, F.J., Rosse, C. Nature (1981)
- Increased junctional diversity in fetal B cells results in a loss of protective anti-phosphorylcholine antibodies in adult mice. Benedict, C.L., Kearney, J.F. Immunity (1999)
- The long isoform of terminal deoxynucleotidyl transferase enters the nucleus and, rather than catalyzing nontemplated nucleotide addition, modulates the catalytic activity of the short isoform. Benedict, C.L., Gilfillan, S., Kearney, J.F. J. Exp. Med. (2001)
- DNA polymerase mu (Pol mu), homologous to TdT, could act as a DNA mutator in eukaryotic cells. Domínguez, O., Ruiz, J.F., Laín de Lera, T., García-Díaz, M., González, M.A., Kirchhoff, T., Martínez-A, C., Bernad, A., Blanco, L. EMBO J. (2000)
- Neuroprotective effects of prostaglandin E2 or cAMP against microglial and neuronal free radical mediated toxicity associated with inflammation. Kim, E.J., Kwon, K.J., Park, J.Y., Lee, S.H., Moon, C.H., Baik, E.J. J. Neurosci. Res. (2002)
- Rifampicin attenuates brain damage in focal ischemia. Yulug, B., Kilic, U., Kilic, E., Bähr, M. Brain Res. (2004)
- Crystal structures of a template-independent DNA polymerase: murine terminal deoxynucleotidyltransferase. Delarue, M., Boulé, J.B., Lescar, J., Expert-Bezançon, N., Jourdan, N., Sukumar, N., Rougeon, F., Papanicolaou, C. EMBO J. (2002)
- Small interfering RNA targeting Fas protects mice against renal ischemia-reperfusion injury. Hamar, P., Song, E., Kökény, G., Chen, A., Ouyang, N., Lieberman, J. Proc. Natl. Acad. Sci. U.S.A. (2004)
- Increased sensitivity to apoptotic stimuli in c-abl-deficient progenitor B-cell lines. Dorsch, M., Goff, S.P. Proc. Natl. Acad. Sci. U.S.A. (1996)
- Three lymphoid-specific factors account for all junctional diversity characteristic of somatic assembly of T-cell receptor and immunoglobulin genes. Kallenbach, S., Doyen, N., Fanton d'Andon, M., Rougeon, F. Proc. Natl. Acad. Sci. U.S.A. (1992)
- Monoclonal antibodies to human terminal transferase. Bollum, F.J., Augl, C., Chang, L.M. J. Biol. Chem. (1984)
- Expression of apoptosis-related proteins in experimental coxsackievirus myocarditis. Colston, J.T., Chandrasekar, B., Freeman, G.L. Cardiovasc. Res. (1998)
- Acute cigarette smoke exposure induces apoptosis of alveolar macrophages. Aoshiba, K., Tamaoki, J., Nagai, A. Am. J. Physiol. Lung Cell Mol. Physiol. (2001)
- The terminal deoxynucleotidyltransferase gene is located on human chromosome 10 (10q23----q24) and on mouse chromosome 19. Yang-Feng, T.L., Landau, N.R., Baltimore, D., Francke, U. Cytogenet. Cell Genet. (1986)
- Murine pro-B cells require IL-7 and its receptor complex to up-regulate IL-7R alpha, terminal deoxynucleotidyltransferase, and c mu expression. Wei, C., Zeff, R., Goldschneider, I. J. Immunol. (2000)
- Apoptosis in congestive heart failure induced by viral myocarditis in mice. Yamada, T., Matsumori, A., Wang, W.Z., Ohashi, N., Shiota, K., Sasayama, S. Heart and vessels. (1999)
- Paradoxical action of fulvestrant in estradiol-induced regression of tamoxifen-stimulated breast cancer. Osipo, C., Gajdos, C., Liu, H., Chen, B., Jordan, V.C. J. Natl. Cancer Inst. (2003)
- An antitumour lectin from the edible mushroom Agrocybe aegerita. Zhao, C., Sun, H., Tong, X., Qi, Y. Biochem. J. (2003)
- Abrogation of cisplatin-induced programmed cell death in human breast cancer cells by epidermal growth factor antisense RNA. Dixit, M., Yang, J.L., Poirier, M.C., Price, J.O., Andrews, P.A., Arteaga, C.L. J. Natl. Cancer Inst. (1997)
- Activated caspase-1 is not a central mediator of inflammation in the course of ischemia-reperfusion. Daemen, M.A., Denecker, G., van't Veer, C., Wolfs, T.G., Vandenabeele, P., Buurman, W.A. Transplantation (2001)
- Role of endogenous Fas (CD95/Apo-1) ligand in balloon-induced apoptosis, inflammation, and neointima formation. Matter, C.M., Chadjichristos, C.E., Meier, P., von Lukowicz, T., Lohmann, C., Schuler, P.K., Zhang, D., Odermatt, B., Hofmann, E., Brunner, T., Kwak, B.R., Lüscher, T.F. Circulation (2006)
- Smad3 deficiency attenuates renal fibrosis, inflammation,and apoptosis after unilateral ureteral obstruction. Inazaki, K., Kanamaru, Y., Kojima, Y., Sueyoshi, N., Okumura, K., Kaneko, K., Yamashiro, Y., Ogawa, H., Nakao, A. Kidney Int. (2004)
- Retinoid-related orphan receptor gamma (RORgamma) is essential for lymphoid organogenesis and controls apoptosis during thymopoiesis. Kurebayashi, S., Ueda, E., Sakaue, M., Patel, D.D., Medvedev, A., Zhang, F., Jetten, A.M. Proc. Natl. Acad. Sci. U.S.A. (2000)
- Resistance of differentiating spermatogonia to radiation-induced apoptosis and loss in p53-deficient mice. Hasegawa, M., Zhang, Y., Niibe, H., Terry, N.H., Meistrich, M.L. Radiat. Res. (1998)
- Use of terminal transferase-dependent antisense RNA amplification to determine the transcription start site of the Snrpn gene in individual neurons. Buettner, V.L., LeBon, J.M., Gao, C., Riggs, A.D., Singer-Sam, J. Nucleic Acids Res. (2000)
- Chromatin fine structure profiles for a developmentally regulated gene: reorganization of the lysozyme locus before trans-activator binding and gene expression. Kontaraki, J., Chen, H.H., Riggs, A., Bonifer, C. Genes Dev. (2000)
- Demonstration of terminal deoxynucleotidyl transferase in thymocytes by immunofluorescence. Goldschneider, I., Gregoire, K.E., Barton, R.W., Bollum, F.J. Proc. Natl. Acad. Sci. U.S.A. (1977)
- Caspase activation and neuroprotection in caspase-3- deficient mice after in vivo cerebral ischemia and in vitro oxygen glucose deprivation. Le, D.A., Wu, Y., Huang, Z., Matsushita, K., Plesnila, N., Augustinack, J.C., Hyman, B.T., Yuan, J., Kuida, K., Flavell, R.A., Moskowitz, M.A. Proc. Natl. Acad. Sci. U.S.A. (2002)