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Gene Review

RNF216  -  ring finger protein 216

Homo sapiens

Synonyms: CAHH, E3 ubiquitin-protein ligase RNF216, RING finger protein 216, TRIAD3, Triad domain-containing protein 3, ...
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Disease relevance of TRIAD3

  • The possible mechanisms by which ZIN interferes with the early events of HIV-1 replication are discussed [1].
  • It was further shown that cells infected with HIV NL4.3 virus stocks produced in the presence of exogenously expressed ZIN were impaired in viral DNA synthesis by twofold [1].

High impact information on TRIAD3

  • Domain mapping experiments indicate that the RING-like zinc finger domains of ZIN are required for its interaction with RIP and inhibition of RIP-mediated NF-kappa B activation [2].
  • Overexpression of ZIN also potentiates RIP- and TNF-induced apoptosis [2].
  • We previously reported the isolation of a Vif-interacting ring finger protein, Triad 3, from a human leukocyte cDNA library, using the yeast two-hybrid system [1].
  • RESULTS: Thus far 3 of these clones, spermine/spermidine N1-acetyltransferase, Triad 3 and a novel gene which we have termed 'novel Vif binding protein', have been characterised and represent attractive candidates for mediating Vif action during HIV replication [3].
  • ZIN was associated with minimal pulpal changes and microbial microleakage, and differed little from the control material, Kalzinol [4].

Biological context of TRIAD3


Analytical, diagnostic and therapeutic context of TRIAD3


  1. Ring finger protein ZIN interacts with human immunodeficiency virus type 1 Vif. Feng, F., Davis, A., Lake, J.A., Carr, J., Xia, W., Burrell, C., Li, P. J. Virol. (2004) [Pubmed]
  2. A novel zinc finger protein interacts with receptor-interacting protein (RIP) and inhibits tumor necrosis factor (TNF)- and IL1-induced NF-kappa B activation. Chen, D., Li, X., Zhai, Z., Shu, H.B. J. Biol. Chem. (2002) [Pubmed]
  3. The role of Vif during HIV-1 infection: interaction with novel host cellular factors. Lake, J.A., Carr, J., Feng, F., Mundy, L., Burrell, C., Li, P. J. Clin. Virol. (2003) [Pubmed]
  4. Pulpal response to two semihydrous glass ionomer luting cements. Tobias, R.S., Browne, R.M., Plant, C.G., Williams, J.A., Rippin, J.W. International endodontic journal. (1991) [Pubmed]
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