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Gene Review

RHOT1  -  ras homolog family member T1

Homo sapiens

Synonyms: ARHT1, FLJ11040, MIRO-1, MIRO1, Mitochondrial Rho GTPase 1, ...
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High impact information on RHOT1


Biological context of RHOT1


Anatomical context of RHOT1

  • It was reported previously that a constitutively active mutant of Miro-1 induced a clustering of the mitochondria [5].
  • Tympanic membrane images were captured and digitized using a Welch-Allyn (Skaneatales Falls, NY) VDX-300 Illumination and Imaging system with S-VHS input to a MIRO DC 30 (Pinnacle Systems, Mountain View, CA) visual board in a Power PC-based computer [6].

Associations of RHOT1 with chemical compounds

  • A certain amount of indium (0.01-1.70 mg/cm2) was solubilized from the surface of only one prosthetic semiprecious brand (Miro Bright) in either 1% lactic acid or 0.05% hydrochloric acid solutions [7].


  1. Paradigm lost: milton connects kinesin heavy chain to miro on mitochondria. Rice, S.E., Gelfand, V.I. J. Cell Biol. (2006) [Pubmed]
  2. Yeast Miro GTPase, Gem1p, regulates mitochondrial morphology via a novel pathway. Frederick, R.L., McCaffery, J.M., Cunningham, K.W., Okamoto, K., Shaw, J.M. J. Cell Biol. (2004) [Pubmed]
  3. Atypical Rho GTPases have roles in mitochondrial homeostasis and apoptosis. Fransson, A., Ruusala, A., Aspenström, P. J. Biol. Chem. (2003) [Pubmed]
  4. Cloning and characterization of the mouse Arht2 gene which encodes a putative atypical GTPase. Shan, Y., Hexige, S., Guo, Z., Wan, B., Chen, K., Chen, X., Ma, L., Huang, C., Zhao, S., Yu, L. Cytogenet. Genome Res. (2004) [Pubmed]
  5. The atypical Rho GTPases Miro-1 and Miro-2 have essential roles in mitochondrial trafficking. Fransson, S., Ruusala, A., Aspenström, P. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  6. Quantitative analysis of tympanic membrane disease using video-otoscopy. Jaisinghani, V.J., Hunter, L.L., Li, Y., Margolis, R.H. Laryngoscope (2000) [Pubmed]
  7. Effects of indium and iron ions on in vitro calcium phosphate precipitation and crystallinity. Hidaka, S., Okamoto, Y., Abe, K., Miyazaki, K. J. Biomed. Mater. Res. (1996) [Pubmed]
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