The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

SYNJ2BP  -  synaptojanin 2 binding protein

Homo sapiens

Synonyms: ARIP2, Arip2, Mitochondrial outer membrane protein 25, OMP25, Synaptojanin-2-binding protein
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of SYNJ2BP

  • Thus, we have analyzed the effects of two major OMPs (Omp25 and Omp31) of Brucella suis 1330 (wild-type [WT] B. suis) on TNF-alpha production [1].
  • We demonstrate the production of three paralogs of Omp31 and/or Omp25 in B. suis, and the existence of a common site of signal peptide cleavage (AXAAD), which is very similar to that present in the five homologous Omps of Bartonella quintana [2].

High impact information on SYNJ2BP

  • Here, we analyzed the import route of mitochondrial outer membrane (MOM) C-TA proteins, Bak, Bcl-XL, and Omp25, using digitonin-permeabilized HeLa cells, which provide specific and efficient import under competitive conditions [3].
  • To test our observation that a peroxisomal location is not required for PEX26 function, we made a chimeric protein (PEX26-Mito) with PEX26 as its N-terminus and the targeting segment of a mitochondrial outer membrane protein (OMP25) at its C-terminus [4].
  • The seven group 3 Omps were classified in four-subgroups on the basis of percentage amino acid sequence identities: Omp25 alone, the Omp25b-Omp25c-Omp25d cluster, the Omp31/31b subgroup, and the less related Omp22 protein (also called Omp3b) [2].
  • These observations demonstrated that Omp25 of B. suis is involved in the negative regulation of TNF-alpha production upon infection of human macrophages [1].
  • Five genes homologous to the well-known omp25 and omp31 genes, that code for two major Brucella spp. outer membrane proteins (OMPs), have been detected in the genome of Brucella melitensis 16M and Brucella suis 1330 [5].

Chemical compound and disease context of SYNJ2BP

  • Latex beads coated with MAb to R-LPS coagglutinated only R strains, whereas latex beads coated with MAb to Omp25 coagglutinated all the R Brucella isolates except Brucella ovis [6].

Associations of SYNJ2BP with chemical compounds

  • Latex beads were coated, via protein A, with either an anti-Brucella rough-lipopolysaccharide (R-LPS) monoclonal antibody (MAb) or an anti-Brucella 25-kDa outer membrane protein (Omp25) MAb [6].

Analytical, diagnostic and therapeutic context of SYNJ2BP

  • Since several monoclonal antibodies (MAbs) against Omp25 cross-reacted with other members of group 3 Omps, we also performed Western immunoblotting to compare wild-type B. suis with mutants systematically having B. suis omp25-related genes knocked out [2].


  1. Major outer membrane protein Omp25 of Brucella suis is involved in inhibition of tumor necrosis factor alpha production during infection of human macrophages. Jubier-Maurin, V., Boigegrain, R.A., Cloeckaert, A., Gross, A., Alvarez-Martinez, M.T., Terraza, A., Liautard, J., Köhler, S., Rouot, B., Dornand, J., Liautard, J.P. Infect. Immun. (2001) [Pubmed]
  2. Characterization of new members of the group 3 outer membrane protein family of Brucella spp. Salhi, I., Boigegrain, R.A., Machold, J., Weise, C., Cloeckaert, A., Rouot, B. Infect. Immun. (2003) [Pubmed]
  3. Cytosolic factor- and TOM-independent import of C-tail-anchored mitochondrial outer membrane proteins. Setoguchi, K., Otera, H., Mihara, K. EMBO J. (2006) [Pubmed]
  4. Alternative splicing suggests extended function of PEX26 in peroxisome biogenesis. Weller, S., Cajigas, I., Morrell, J., Obie, C., Steel, G., Gould, S.J., Valle, D. Am. J. Hum. Genet. (2005) [Pubmed]
  5. DNA polymorphism in the omp25/omp31 family of Brucella spp.: identification of a 1.7-kb inversion in Brucella cetaceae and of a 15.1-kb genomic island, absent from Brucella ovis, related to the synthesis of smooth lipopolysaccharide. Vizcaíno, N., Caro-Hernández, P., Cloeckaert, A., Fernández-Lago, L. Microbes Infect. (2004) [Pubmed]
  6. Rapid identification of rough Brucella isolates by a latex coagglutination assay with the 25-kilodalton outer membrane protein and rough-lipopolysaccharide-specific monoclonal antibodies. Bowden, R.A., Verger, J.M., Grayon, M., Cloeckaert, A. Clin. Diagn. Lab. Immunol. (1997) [Pubmed]
WikiGenes - Universities