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Gene Review

STRADB  -  STE20-related kinase adaptor beta

Homo sapiens

Synonyms: ALS2CR2, Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein, CALS-21, ILP-interacting protein, ILPIP, ...
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Disease relevance of ALS2CR2


High impact information on ALS2CR2

  • We demonstrate that the complex formation between LKB1.Par-4, PAPK, and Mo25 results in the translocation of LKB1 from the nucleus to the cytoplasm and to tight junctions and show that the LKB1 complex may activate MARKs, which are known to introduce 14-3-3 binding sites into several substrates [2].
  • PAPK shares homology with members of the Ste20/germinal center kinase family of protein kinases and is ubiquitously expressed as two spliced forms, PAPK-A and PAPK-B, that encode for proteins of 418 and 189 amino acids, respectively [1].
  • When an inducible construct of PAPK-A was expressed in stably transfected NIH3T3 cells, the cells exhibited distinct cytoskeletal changes and became resistant to apoptotic cell death induced by serum withdrawal, effects of PAPK that require its kinase activity [1].
  • ILPIP moderately protects against interleukin-1beta converting enzyme- or Fas-induced apoptosis and significantly potentiates the anti-apoptotic activity of XIAP [3].

Biological context of ALS2CR2


  1. Identification and characterization of a novel Ste20/germinal center kinase-related kinase, polyploidy-associated protein kinase. Nishigaki, K., Thompson, D., Yugawa, T., Rulli, K., Hanson, C., Cmarik, J., Gutkind, J.S., Teramoto, H., Ruscetti, S. J. Biol. Chem. (2003) [Pubmed]
  2. Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network. Brajenovic, M., Joberty, G., Küster, B., Bouwmeester, T., Drewes, G. J. Biol. Chem. (2004) [Pubmed]
  3. ILPIP, a novel anti-apoptotic protein that enhances XIAP-mediated activation of JNK1 and protection against apoptosis. Sanna, M.G., da Silva Correia, J., Luo, Y., Chuang, B., Paulson, L.M., Nguyen, B., Deveraux, Q.L., Ulevitch, R.J. J. Biol. Chem. (2002) [Pubmed]
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