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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

EXOC2  -  exocyst complex component 2

Homo sapiens

Synonyms: Exocyst complex component 2, Exocyst complex component Sec5, FLJ11026, SEC5, SEC5L1, ...
 
 
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High impact information on EXOC2

  • These observations define the mechanistic contribution of RalGTPases to cancer cell survival and reveal the RalB/Sec5 effector complex as a component of TBK1-dependent innate immune signaling [1].
  • Reported effector proteins of RalB include the Sec5 component of the exocyst, an octameric protein complex implicated in tethering of vesicles to membranes [1].
  • In agreement with this idea, EGF-induced lamellipodia formation was promoted by the overexpression of Akt and inhibited by an Akt inhibitor or a Ral-binding domain of Sec5 [2].
  • DelGEF was recently shown to interact with Sec5, a protein involved in secretion, and to regulate secretion of proteoglycans [3].
  • Labetalol significantly reduced vascular resistance (-339 dynes X cm/sec5), but atenolol and propranolol did not (147 vs. 62 dynes X cm/sec5) [4].
 

Anatomical context of EXOC2

  • The human homologue of Sec5, a protein involved in vesicle transport and secretion, was identified as a binding partner [5].
 

Associations of EXOC2 with chemical compounds

  • DelGEF, a homologue of the Ran guanine nucleotide exchange factor RanGEF, binds to the exocyst component Sec5 and modulates secretion [5].
 

Analytical, diagnostic and therapeutic context of EXOC2

  • To examine this possibility, we cloned and sequenced the SEC5 and SEC10 genes, disrupted them, and either epitope tagged them (Sec5p) or prepared polyclonal antisera (Sec10p) to them for co-immunoprecipitation studies [6].

References

  1. RalB GTPase-Mediated Activation of the IkappaB Family Kinase TBK1 Couples Innate Immune Signaling to Tumor Cell Survival. Chien, Y., Kim, S., Bumeister, R., Loo, Y.M., Kwon, S.W., Johnson, C.L., Balakireva, M.G., Romeo, Y., Kopelovich, L., Gale, M., Yeaman, C., Camonis, J.H., Zhao, Y., White, M.A. Cell (2006) [Pubmed]
  2. Akt-PDK1 Complex Mediates Epidermal Growth Factor-induced Membrane Protrusion through Ral Activation. Yoshizaki, H., Mochizuki, N., Gotoh, Y., Matsuda, M. Mol. Biol. Cell (2007) [Pubmed]
  3. Characterisation of an evolutionary conserved protein interacting with the putative guanine nucleotide exchange factor DelGEF and modulating secretion. Sjölinder, M., Uhlmann, J., Ponstingl, H. Exp. Cell Res. (2004) [Pubmed]
  4. The effects of single-dose atenolol, labetalol, and propranolol on cardiac and vascular function. Holtzman, J.L., Finley, D., Johnson, B., Berry, D.A., Sirgo, M.A. Clin. Pharmacol. Ther. (1986) [Pubmed]
  5. DelGEF, a homologue of the Ran guanine nucleotide exchange factor RanGEF, binds to the exocyst component Sec5 and modulates secretion. Sjölinder, M., Uhlmann, J., Ponstingl, H. FEBS Lett. (2002) [Pubmed]
  6. The Exocyst is a multiprotein complex required for exocytosis in Saccharomyces cerevisiae. TerBush, D.R., Maurice, T., Roth, D., Novick, P. EMBO J. (1996) [Pubmed]
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