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Gene Review

Hes6  -  hairy and enhancer of split 6

Mus musculus

Synonyms: AI326893, Hairy and enhancer of split 6, Transcription cofactor HES-6, bHLHb41
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High impact information on Hes6

  • Hes6 regulates myogenic differentiation [1].
  • When overexpressed in C2C12 cells, Hes6 impairs normal differentiation, causing a decrease in the induction of the cyclin-dependent kinase inhibitor, p21(Cip1), and an increase in the number of cells that can be recruited back into the cell cycle after differentiation in culture [1].
  • Hes6 binds DNA containing the Enhancer of Split E box (ESE) motif, the preferred binding site of Drosophila EoS proteins, and represses transcription of an ESE box reporter [1].
  • Analysis of Hes6 mutants indicates that the DNA-binding activity of Hes6 is not essential for its myogenic phenotype, but that protein-protein interactions are [1].
  • We show that Hes6 is expressed in the murine embryonic myotome and is induced on C2C12 myoblast differentiation in vitro [1].

Anatomical context of Hes6

  • The bHLH transcription factors, Hes6 and Mash1, are expressed in distinct subsets of cells within adult mouse taste buds [2].
  • We find that Hes6 is expressed in a subset of basally located, possibly progenitor cells, yet is rarely coexpressed with taste cell markers [2].
  • Microinjection of Hes6 RNA in vivo in Xenopus embryos results in an expansion of the myotome, but suppression of terminal muscle differentiation and disruption of somite formation at the tailbud stage [1].
  • In contrast, Mash1 and Hes6 are restricted to only a few epithelial cells in the apical region of the developing papilla [3].
  • In the VNO, Hes6 was expressed throughout the sensory epithelium (S-VNO) at embryonic day 12, and later became restricted to a single layer of cells in the basal region of the S-VNO, where Hes5-expressing undifferentiated cells were present [4].

Other interactions of Hes6

  • At E14.5, when Hes6 and Mash1 are already expressed in small numbers of epithelial cells, PGP9.5 immunoreactive fibers have not yet invaded the epithelium, consistent with the specification of taste bud primordia prior to nerve contact [3].
  • Basic helix-loop-helix transcription factors NeuroD and Hes6 promote neuronal differentiation [4].

Analytical, diagnostic and therapeutic context of Hes6


  1. Hes6 regulates myogenic differentiation. Cossins, J., Vernon, A.E., Zhang, Y., Philpott, A., Jones, P.H. Development (2002) [Pubmed]
  2. The bHLH transcription factors, Hes6 and Mash1, are expressed in distinct subsets of cells within adult mouse taste buds. Seta, Y., Stoick-Cooper, C.L., Toyono, T., Kataoka, S., Toyoshima, K., Barlow, L.A. Arch. Histol. Cytol. (2006) [Pubmed]
  3. Notch-associated gene expression in embryonic and adult taste papillae and taste buds suggests a role in taste cell lineage decisions. Seta, Y., Seta, C., Barlow, L.A. J. Comp. Neurol. (2003) [Pubmed]
  4. Expression of Hes6 and NeuroD in the olfactory epithelium, vomeronasal organ and non-sensory patches. Suzuki, Y., Mizoguchi, I., Nishiyama, H., Takeda, M., Obara, N. Chem. Senses (2003) [Pubmed]
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