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Gene Review

Ggcx  -  gamma-glutamyl carboxylase

Mus musculus

Synonyms: Gamma-glutamyl carboxylase, Peptidyl-glutamate 4-carboxylase, Vitamin K gamma glutamyl carboxylase, Vitamin K-dependent gamma-carboxylase, vitamin K-dependent carboxylase
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Disease relevance of Ggcx


High impact information on Ggcx


Enzymatic interactions of Ggcx

  • The liver microsomal vitamin K-dependent carboxylase catalyzes the post-translational conversion of specific glutamyl to gamma-carboxyglutamyl (Gla) residues in precursor forms of a limited number of proteins [7].


  1. B16 tumor cells contain a warfarin sensitive vitamin K1 2,3 epoxide reductase. Uitendaal, M.P., Thijssen, H.H., Drittij-Reijnders, M.J., Hoeijmakers, M.J. Biochem. Biophys. Res. Commun. (1986) [Pubmed]
  2. gamma-Glutamyl carboxylase activity in experimental tumor tissues: a biochemical basis for vitamin K dependence of cancer procoagulant. Roncaglioni, M.C., Dalessandro, A.P., Casali, B., Vermeer, C., Donati, M.B. Haemostasis (1986) [Pubmed]
  3. A conserved motif within the vitamin K-dependent carboxylase gene is widely distributed across animal phyla. Begley, G.S., Furie, B.C., Czerwiec, E., Taylor, K.L., Furie, G.L., Bronstein, L., Stenflo, J., Furie, B. J. Biol. Chem. (2000) [Pubmed]
  4. Vitamin K-dependent carboxylase in skin. de Boer-van den Berg, M.A., Verstijnen, C.P., Vermeer, C. J. Invest. Dermatol. (1986) [Pubmed]
  5. Expression and characterization of recombinant vitamin K-dependent gamma-glutamyl carboxylase from an invertebrate, Conus textile. Czerwiec, E., Begley, G.S., Bronstein, M., Stenflo, J., Taylor, K., Furie, B.C., Furie, B. Eur. J. Biochem. (2002) [Pubmed]
  6. Novel mechanisms in accelerated vascular calcification in renal disease patients. Demer, L.L., Tintut, Y., Parhami, F. Curr. Opin. Nephrol. Hypertens. (2002) [Pubmed]
  7. Vitamin K-dependent carboxylase: influence of the "propeptide" region on enzyme activity. Cheung, A., Engelke, J.A., Sanders, C., Suttie, J.W. Arch. Biochem. Biophys. (1989) [Pubmed]
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