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Gene Review

Ctsf  -  cathepsin F

Mus musculus

Synonyms: AI481912, Cathepsin F
 
 
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High impact information on Ctsf

  • Cathepsin F (cat F) is a widely expressed lysosomal cysteine protease whose in vivo role is unknown [1].
  • The gene encoding cathepsin F maps to chromosome 11q13, close to that encoding cathepsin W [2].
  • A cDNA encoding a new cysteine proteinase belonging to the papain family and called cathepsin F has been cloned from a human prostate cDNA library [2].
  • Cathepsin F also shows all structural motifs characteristic of these proteinases, including the essential cysteine residue of the active site [2].
  • The mouse cathepsin F gene consists of 14 exons and 13 introns and spans 5.8kb [3].
 

Biological context of Ctsf

 

Associations of Ctsf with chemical compounds

 

Analytical, diagnostic and therapeutic context of Ctsf

  • Molecular cloning and structural and functional characterization of human cathepsin F, a new cysteine proteinase of the papain family with a long propeptide domain [2].
  • Northern blot analysis of RNA from multiple tissues revealed a ubiquitous expression of cathepsin F in mouse and man [3].

References

  1. Murine cathepsin F deficiency causes neuronal lipofuscinosis and late-onset neurological disease. Tang, C.H., Lee, J.W., Galvez, M.G., Robillard, L., Mole, S.E., Chapman, H.A. Mol. Cell. Biol. (2006) [Pubmed]
  2. Molecular cloning and structural and functional characterization of human cathepsin F, a new cysteine proteinase of the papain family with a long propeptide domain. Santamaría, I., Velasco, G., Pendás, A.M., Paz, A., López-Otín, C. J. Biol. Chem. (1999) [Pubmed]
  3. Mouse cathepsin F: cDNA cloning, genomic organization and chromosomal assignment of the gene. Deussing, J., Tisljar, K., Papazoglou, A., Peters, C. Gene (2000) [Pubmed]
  4. Cathepsins F and S block HDL3-induced cholesterol efflux from macrophage foam cells. Lindstedt, L., Lee, M., Oörni, K., Brömme, D., Kovanen, P.T. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
 
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