High impact information on Ctsf

• Cathepsin F (cat F) is a widely expressed lysosomal cysteine protease whose in vivo role is unknown [1].
• The gene encoding cathepsin F maps to chromosome 11q13, close to that encoding cathepsin W [2].
• A cDNA encoding a new cysteine proteinase belonging to the papain family and called cathepsin F has been cloned from a human prostate cDNA library [2].
• Cathepsin F also shows all structural motifs characteristic of these proteinases, including the essential cysteine residue of the active site [2].
• The mouse cathepsin F gene consists of 14 exons and 13 introns and spans 5.8kb [3].

Biological context of Ctsf

• Murine cathepsin F was mapped to chromosome 19, a region with synteny homology to a region of human chromosome 11 to which human cathepsin F has been mapped previously [3].

Associations of Ctsf with chemical compounds

• Incubation of HDL(3) with cathepsin F or S, but not with cathepsin K, led to rapid loss of prebeta-HDL, and reduced cholesterol efflux by 50% in only 1min [4].

Analytical, diagnostic and therapeutic context of Ctsf

• Molecular cloning and structural and functional characterization of human cathepsin F, a new cysteine proteinase of the papain family with a long propeptide domain [2].
• Northern blot analysis of RNA from multiple tissues revealed a ubiquitous expression of cathepsin F in mouse and man [3].

References