Disease relevance of Asna1

• The plasmid encoded ArsA ATPase in Escherichia coli is the catalytic component of an oxyanion pump that is responsible for resistance to arsenicals and antimonials [1].

High impact information on Asna1

• The Asna1+/- mice displayed similar phenotype as the wild-type mice [2].
• These findings indicate that Asna1 plays a crucial role during early embryonic development [2].
• The bacterial ArsA ATPase is the catalytic component of an oxyanion pump that is responsible for resistance to arsenicals and antimonials [2].
• A negligible amount of Asna1 transcript is detected in skeletal muscle [1].
• Fluorescence in situ hybridization indicates that the Asna1 gene is localized in the C3-D1 region of mouse chromosome 8 [1].

Biological context of Asna1

• The Asna1 gene encodes an open reading frame of 348 amino acids and exhibits 27% identity to the bacterial ArsA protein and 99% similarity to its human counterpart (hASNA-1) [1].
• These results indicate that hASNA-I is a paralogue of the bacterial ArsA protein and suggest that it plays a role in the nucleocytoplasmic transport of a nucleolar component [3].

Anatomical context of Asna1

• The Asna1 mRNA is a approximately 1.3 kb transcript and is present at high levels in kidney and testis, moderate levels in brain, liver, lung and skin, and low levels in heart, small intestine, spleen, stomach, and thymus [1].

Associations of Asna1 with chemical compounds

• Arsenite or antimonite allosterically activates the ArsA ATPase activity [1].

References