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Gene Review

Asna1  -  arsA arsenite transporter, ATP-binding,...

Mus musculus

Synonyms: 1810048H22Rik, ATPase Asna1, ArsA, Arsa, Arsenical pump-driving ATPase, ...
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Disease relevance of Asna1


High impact information on Asna1


Biological context of Asna1

  • The Asna1 gene encodes an open reading frame of 348 amino acids and exhibits 27% identity to the bacterial ArsA protein and 99% similarity to its human counterpart (hASNA-1) [1].
  • These results indicate that hASNA-I is a paralogue of the bacterial ArsA protein and suggest that it plays a role in the nucleocytoplasmic transport of a nucleolar component [3].

Anatomical context of Asna1

  • The Asna1 mRNA is a approximately 1.3 kb transcript and is present at high levels in kidney and testis, moderate levels in brain, liver, lung and skin, and low levels in heart, small intestine, spleen, stomach, and thymus [1].

Associations of Asna1 with chemical compounds


  1. Genomic organization and chromosomal localization of the Asna1 gene, a mouse homologue of a bacterial arsenic-translocating ATPase gene. Bhattacharjee, H., Ho, Y.S., Rosen, B.P. Gene (2001) [Pubmed]
  2. Targeted disruption of the mouse Asna1 gene results in embryonic lethality. Mukhopadhyay, R., Ho, Y.S., Swiatek, P.J., Rosen, B.P., Bhattacharjee, H. FEBS Lett. (2006) [Pubmed]
  3. Dual cytoplasmic and nuclear distribution of the novel arsenite-stimulated human ATPase (hASNA-I). Kurdi-Haidar, B., Hom, D.K., Flittner, D.E., Heath, D., Fink, L., Naredi, P., Howell, S.B. J. Cell. Biochem. (1998) [Pubmed]
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