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Gene Review

Nop2  -  NOP2 nucleolar protein

Mus musculus

Synonyms: 120kDa, A530002O17, Nol1, Nucleolar protein 1, Nucleolar protein 2 homolog, ...
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Disease relevance of Nol1


Psychiatry related information on Nol1

  • Since nuclear tau has also been found in neurons from patients with Alzheimer's disease (AD), aberrant nuclear tau could affect the nucleolar organization during the course of AD [3].

High impact information on Nol1


Biological context of Nol1

  • Our findings suggest that the cytoplasm of activated (but not nonactivated) 1-cell embryos is capable of influencing the nucleolar activity of the introduced 8- to 16-cell nuclei, effectively erasing from their chromosomes the memory of at least three previous rounds of rRNA synthesis [7].
  • We discuss nucleolar tau associated with AT-rich alpha-satellite DNA sequences as a potential molecular link between trisomy 21 and AD [3].
  • If hybridization is effected with pronucleate oocytes, the thymocyte nucleus retains its interphase character but shows particular modifications in nucleolar morphology (identical to changes observed during reactivation of the nucleolus in stimulated lymphocyte) and in the activity of the nuclear envelope (blebbing) [8].
  • In the course of nucleolar activation, the centromeres within the separate clusters became fused into larger centromeric bodies [9].
  • The methylated paternal genome undergoing active DNA demethylation in the enlarging pronucleus was dispersed, assembled, and then migrated to the nucleolar rim [10].

Anatomical context of Nol1


Associations of Nol1 with chemical compounds

  • PROG also induced a subcellular redistribution of BDNF protein, which in controls and steroid-naive Wobblers showed a predominant perinuclear and nucleolar location, whereas after PROG treatment, it was detected in cytoplasmic aggregates [14].
  • We have studied, at the electron microscope level, the reorganizations of nucleolar ultrastructure induced by actinomycin D (AMD) in different conditions of drug treatment associated with an inhibition of rRNA synthesis [15].
  • CH3HgCl (MeHg) induced in SJL, A.SW and B10.S mice antinucleolar antibodies (ANoA) targeting the nucleolar 34-kDa protein fibrillarin [16].
  • Changes of silver-stained nucleolar organizer regions in mouse endometrial carcinogenesis induced by N-methyl-N-nitrosourea and 17 beta-oestradiol [17].

Other interactions of Nol1

  • RNA polymerase I was not cytochemically detected in the nucleolar structure, which contained only small amounts of fibrillarin [9].

Analytical, diagnostic and therapeutic context of Nol1


  1. Mouse mammary tumor virus Env-derived peptide associates with nucleolar targets in lymphoma, mammary carcinoma, and human breast cancer. Bar-Sinai, A., Bassa, N., Fischette, M., Gottesman, M.M., Love, D.C., Hanover, J.A., Hochman, J. Cancer Res. (2005) [Pubmed]
  2. A class of nonribosomal nucleolar components is located in chromosome periphery and in nucleolus-derived foci during anaphase and telophase. Dundr, M., Meier, U.T., Lewis, N., Rekosh, D., Hammarskjöld, M.L., Olson, M.O. Chromosoma (1997) [Pubmed]
  3. Tau protein binds to pericentromeric DNA: a putative role for nuclear tau in nucleolar organization. Sjöberg, M.K., Shestakova, E., Mansuroglu, Z., Maccioni, R.B., Bonnefoy, E. J. Cell. Sci. (2006) [Pubmed]
  4. A short mitochondrial form of p19ARF induces autophagy and caspase-independent cell death. Reef, S., Zalckvar, E., Shifman, O., Bialik, S., Sabanay, H., Oren, M., Kimchi, A. Mol. Cell (2006) [Pubmed]
  5. Growth inhibition of estrogen-dependent and estrogen-independent MXT mammary cancers in mice by the bombesin and gastrin-releasing peptide antagonist RC-3095. Szepeshazi, K., Schally, A.V., Halmos, G., Groot, K., Radulovic, S. J. Natl. Cancer Inst. (1992) [Pubmed]
  6. Evolutionarily Conserved Role of Nucleostemin: Controlling Proliferation of Stem/Progenitor Cells during Early Vertebrate Development. Beekman, C., Nichane, M., De Clercq, S., Maetens, M., Floss, T., Wurst, W., Bellefroid, E., Marine, J.C. Mol. Cell. Biol. (2006) [Pubmed]
  7. Cytogenetic study of silver-staining NOR in 8-cell-stage mouse blastomeres fused to 1-cell-stage embryos. Dyban, A.P., Lee, K., O'Neill, G.T., Speirs, S., Kaufman, M.H. Development (1988) [Pubmed]
  8. Remodeling of mouse thymocyte nuclei depends on the time of their transfer into activated, homologous oocytes. Szöllösi, D., Czołowska, R., Szöllösi, M.S., Tarkowski, A.K. J. Cell. Sci. (1988) [Pubmed]
  9. Nucleolar transcriptional activity in mouse Sertoli cells is dependent on centromere arrangement. Haaf, T., Steinlein, C., Schmid, M. Exp. Cell Res. (1990) [Pubmed]
  10. Time-lapse and retrospective analysis of DNA methylation in mouse preimplantation embryos by live cell imaging. Yamazaki, T., Yamagata, K., Baba, T. Dev. Biol. (2007) [Pubmed]
  11. Identification and characterization of a human proliferation-associated nucleolar antigen with a molecular weight of 120,000 expressed in early G1 phase. Freeman, J.W., Busch, R.K., Gyorkey, F., Gyorkey, P., Ross, B.E., Busch, H. Cancer Res. (1988) [Pubmed]
  12. Chemoprevention of mouse urinary bladder carcinogenesis by the naturally occurring carotenoid astaxanthin. Tanaka, T., Morishita, Y., Suzui, M., Kojima, T., Okumura, A., Mori, H. Carcinogenesis (1994) [Pubmed]
  13. Characterization of dp6troglycan-laminin interaction in peripheral nerve. Yamada, H., Chiba, A., Endo, T., Kobata, A., Anderson, L.V., Hori, H., Fukuta-Ohi, H., Kanazawa, I., Campbell, K.P., Shimizu, T., Matsumura, K. J. Neurochem. (1996) [Pubmed]
  14. Progesterone modulates brain-derived neurotrophic factor and choline acetyltransferase in degenerating Wobbler motoneurons. Gonzalez Deniselle, M.C., Garay, L., Gonzalez, S., Saravia, F., Labombarda, F., Guennoun, R., Schumacher, M., De Nicola, A.F. Exp. Neurol. (2007) [Pubmed]
  15. Alterations of nucleolar ultrastructure and ribosome biogenesis by actinomycin D. Implications for U3 snRNP function. Puvion-Dutilleul, F., Mazan, S., Nicoloso, M., Pichard, E., Bachellerie, J.P., Puvion, E. Eur. J. Cell Biol. (1992) [Pubmed]
  16. Methyl mercury-induced autoimmunity in mice. Hultman, P., Hansson-Georgiadis, H. Toxicol. Appl. Pharmacol. (1999) [Pubmed]
  17. Changes of silver-stained nucleolar organizer regions in mouse endometrial carcinogenesis induced by N-methyl-N-nitrosourea and 17 beta-oestradiol. Niwa, K., Yokoyama, Y., Furui, T., Tanaka, T., Mori, H., Mori, H., Tamaya, T. Virchows Archiv. A, Pathological anatomy and histopathology. (1992) [Pubmed]
  18. Oncogenic activation of the human trk proto-oncogene by recombination with the ribosomal large subunit protein L7a. Ziemiecki, A., Müller, R.G., Fu, X.C., Hynes, N.E., Kozma, S. EMBO J. (1990) [Pubmed]
  19. Early stages of pre-rRNA formation within the nucleolar ultrastructure of mouse cells studied by in situ hybridization with a 5'ETS leader probe. Puvion-Dutilleul, F., Puvion, E., Bachellerie, J.P. Chromosoma (1997) [Pubmed]
  20. Murine genotype influences the specificity, magnitude and persistence of murine mercury-induced autoimmunity. Hultman, P., Turley, S.J., Eneström, S., Lindh, U., Pollard, K.M. J. Autoimmun. (1996) [Pubmed]
  21. Demonstration of the nucleolar organizer region by silver staining (AgNOR method) in research and in histopathological practice. Kodousek, R., Dusek, J. Acta Universitatis Palackianae Olomucensis Facultatis Medicae. (1991) [Pubmed]
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