Disease relevance of ASNA1

• We have previously reported the cloning of hASNA-I, a human homologue of arsA encoding the ATPase component of the Escherichia coli arsenite transporter [1].
• Its subcellular localization in human malignant melanoma T289 cells was examined to gain insight into the role of hASNA-I in the physiology of human cells [2].
• Immunohistochemical staining showed a distinct pattern of hASNA-I expression in cells within normal tissues, and its overexpression in breast cancer [3].
• Immunohistochemical analysis of the distribution of the human ATPase (hASNA-I) in normal tissues and its overexpression in breast adenomas and carcinomas [4].
• ASNA independent study. Fibromyalgia [5].

High impact information on ASNA1

• Subsequent release from TRC40/Asna-1 and insertion into the membrane depends on ATP hydrolysis [6].
• Biochemical characterization of the human arsenite-stimulated ATPase (hASNA-I) [1].
• Southern and Northern analyses indicated the presence of two cross-hybridizing genes in the human genome and expression of hARSA-I in many tissues [7].
• We have isolated the human homolog of the bacterial arsA (hARSA-I), a member of the ATPase superfamily with no transmembrane domain [7].
• Further immunocytochemical analysis showed that the hASNA-I at the nuclear membrane was associated with invaginations into the nucleus in interphase cells [2].

Chemical compound and disease context of ASNA1

• The results indicate that hASNA-I is a distinct human arsenite-stimulated ATPase belonging to the same superfamily of ATPases represented by the E. coli ArsA protein [1].

Biological context of ASNA1

• Our results indicate that the coding region of hASNA-I consists of 4 exons spanning 6 kb on band 19q13 [3].
• Recently, the yeast two-hybrid system has identified hASNA-I as a cellular partner of metallothionein II suggesting an additional role in Zn homeostasis and cellular detoxification [3].
• This report describes the assignment of hASNA-I to human chromosome 19 by somatic-cell hybrid PCR mapping, the isolation of a chromosome 19-specific cosmid clone, and the genomic structure and exon-intron boundaries of hASNA-I [3].
• The arsenate and arsenite translocating ATPase consists of 3 polypeptides (from DNA sequence analysis), including a recognizable ATP binding protein (arsA), an integral membrane protein (arsB gene), and a substrate specificity subunit (arsC gene) [8].

Associations of ASNA1 with chemical compounds

• ASNA independent study activity: "Selective serotoni inhibitors (SSRIs)--what nurses should know" [9].

References