Gene Review:
ITGA2B - integrin, alpha 2b (platelet glycoprotein...
Homo sapiens
Synonyms:
BDPLT16, BDPLT2, CD41, CD41B, GP2B, ...
Mor-Cohen,
Pignatti,
Chandy,
Winders,
Stranieri,
Macaya,
Srivastava,
Canciani,
Mitchell,
Salomon,
Usher,
Coller,
Angiolillo,
Alfonso,
Nair,
Landau,
Peake,
Tolbert,
Seligsohn,
Naik,
Nelson,
Koziol,
Rosenberg,
Mondala,
Sabaté,
Bernardo,
Head,
Peretz,
Federici,
Baronciani,
Chismar,
Fernández,
Naik,
Kunicki,
Markovitz,
French,
Fernandez-Ortiz,
Trabetti,
- Molecular diversity of Glanzmann thrombasthenia in southern India: new insights into mRNA splicing and structure-function correlations of alphaIIbbeta3 integrin (ITGA2B, ITGB3). Peretz, H., Rosenberg, N., Landau, M., Usher, S., Nelson, E.J., Mor-Cohen, R., French, D.L., Mitchell, B.W., Nair, S.C., Chandy, M., Coller, B.S., Srivastava, A., Seligsohn, U. Hum. Mutat. (2006)
- Platelet glycoprotein IIb. Chromosomal localization and tissue expression. Bray, P.F., Rosa, J.P., Johnston, G.I., Shiu, D.T., Cook, R.G., Lau, C., Kan, Y.W., McEver, R.P., Shuman, M.A. J. Clin. Invest. (1987)
- Calpain proteolysis of von Willebrand factor enhances its binding to platelet membrane glycoprotein IIb/IIIa: an explanation for platelet aggregation in thrombotic thrombocytopenic purpura. Moore, J.C., Murphy, W.G., Kelton, J.G. Br. J. Haematol. (1990)
- Gene frequencies of the human platelet antigen-3 in different populations. Wiwanitkit, V. Clin. Appl. Thromb. Hemost. (2005)
- Glycoprotein IIb/IIIa receptor antagonists inhibit the development of platelet procoagulant activity. Pedicord, D.L., Thomas, B.E., Mousa, S.A., Dicker, I.B. Thromb. Res. (1998)
- PlA polymorphism and platelet reactivity following clopidogrel loading dose in patients undergoing coronary stent implantation. Angiolillo, D.J., Fernandez-Ortiz, A., Bernardo, E., Alfonso, F., Sabaté, M., Fernández, C., Stranieri, C., Trabetti, E., Pignatti, P.F., Macaya, C. Blood Coagul. Fibrinolysis (2004)
- Increased serotonin receptor density and platelet GPIIb/IIIa activation among smokers. Markovitz, J.H., Tolbert, L., Winders, S.E. Arterioscler. Thromb. Vasc. Biol. (1999)
- Use of the PFA-100 apparatus to assess platelet function in patients undergoing PTCA during and after infusion of c7E3 Fab in the presence of other antiplatelet agents. Hézard, N., Metz, D., Nazeyrollas, P., Droulle, C., Elaerts, J., Potron, G., Nguyen, P. Thromb. Haemost. (2000)
- Polymorphisms in wolframin (WFS1) gene are possibly related to increased risk for mood disorders. Koido, K., Kõks, S., Nikopensius, T., Maron, E., Altmäe, S., Heinaste, E., Vabrit, K., Tammekivi, V., Hallast, P., Kurg, A., Shlik, J., Vasar, V., Metspalu, A., Vasar, E. Int. J. Neuropsychopharmacol. (2005)
- Inhibition of von Willebrand factor-platelet interaction by fibrinogen. Piétu, G., Cherel, G., Marguerie, G., Meyer, D. Nature (1984)
- Platelet membrane glycoprotein IIb/IIIa: member of a family of Arg-Gly-Asp--specific adhesion receptors. Pytela, R., Pierschbacher, M.D., Ginsberg, M.H., Plow, E.F., Ruoslahti, E. Science (1986)
- Thrombin-induced platelet membrane glycoprotein IIb and IIIa complex formation. An electron microscope study. Polley, M.J., Leung, L.L., Clark, F.Y., Nachman, R.L. J. Exp. Med. (1981)
- Inhibition of platelet-mediated, tissue factor-induced thrombin generation by the mouse/human chimeric 7E3 antibody. Potential implications for the effect of c7E3 Fab treatment on acute thrombosis and "clinical restenosis". Reverter, J.C., Béguin, S., Kessels, H., Kumar, R., Hemker, H.C., Coller, B.S. J. Clin. Invest. (1996)
- Major mutations in calf-1 and calf-2 domains of glycoprotein IIb in patients with Glanzmann thrombasthenia enable GPIIb/IIIa complex formation, but impair its transport from the endoplasmic reticulum to the Golgi apparatus. Rosenberg, N., Yatuv, R., Sobolev, V., Peretz, H., Zivelin, A., Seligsohn, U. Blood (2003)
- Anti-thrombotic effects and bleeding risk of AJvW-2, a monoclonal antibody against human von Willebrand factor. Kageyama, S., Yamamoto, H., Nagano, M., Arisaka, H., Kayahara, T., Yoshimoto, R. Br. J. Pharmacol. (1997)
- Lotrafiban: an oral platelet glycoprotein IIb/IIIa blocker. Liu, F., Craft, R.M., Morris, S.A., Carroll, R.C. Expert opinion on investigational drugs. (2000)
- Antithrombotic properties of L-cysteine, N-(mercaptoacetyl)-D-Tyr-Arg-Gly-Asp-sulfoxide (G4120) in a hamster platelet-rich femoral vein thrombosis model. Imura, Y., Stassen, J.M., Bunting, S., Stockmans, F., Collen, D. Blood (1992)
- Blockade of GPIIb/IIIa by eptifibatide and tirofiban does not alter tissue factor induced thrombin generation in human endotoxemia. Derhaschnig, U., Pachinger, C., Schweeger-Exeli, I., Marsik, C., Jilma, B. Thromb. Haemost. (2003)
- An association of candidate gene haplotypes and bleeding severity in von Willebrand disease (VWD) type 1 pedigrees. Kunicki, T.J., Federici, A.B., Salomon, D.R., Koziol, J.A., Head, S.R., Mondala, T.S., Chismar, J.D., Baronciani, L., Canciani, M.T., Peake, I.R. Blood (2004)
- A deletion in the gene for glycoprotein IIb associated with Glanzmann's thrombasthenia. Burk, C.D., Newman, P.J., Lyman, S., Gill, J., Coller, B.S., Poncz, M. J. Clin. Invest. (1991)
- Glanzmann thrombasthenia resulting from a single amino acid substitution between the second and third calcium-binding domains of GPIIb. Role of the GPIIb amino terminus in integrin subunit association. Wilcox, D.A., Paddock, C.M., Lyman, S., Gill, J.C., Newman, P.J. J. Clin. Invest. (1995)
- Structure of platelet glycoprotein IIIa. A common subunit for two different membrane receptors. Zimrin, A.B., Eisman, R., Vilaire, G., Schwartz, E., Bennett, J.S., Poncz, M. J. Clin. Invest. (1988)
- Glanzmann thrombasthenia secondary to a Gly273-->Asp mutation adjacent to the first calcium-binding domain of platelet glycoprotein IIb. Poncz, M., Rifat, S., Coller, B.S., Newman, P.J., Shattil, S.J., Parrella, T., Fortina, P., Bennett, J.S. J. Clin. Invest. (1994)
- Platelet glycoproteins IIb and IIIa: evidence for a family of immunologically and structurally related glycoproteins in mammalian cells. Charo, I.F., Fitzgerald, L.A., Steiner, B., Rall, S.C., Bekeart, L.S., Phillips, D.R. Proc. Natl. Acad. Sci. U.S.A. (1986)
- Polymorphism of human platelet membrane glycoprotein IIb associated with the Baka/Bakb alloantigen system. Lyman, S., Aster, R.H., Visentin, G.P., Newman, P.J. Blood (1990)
- Coordinated signaling through both G12/13 and G(i) pathways is sufficient to activate GPIIb/IIIa in human platelets. Dorsam, R.T., Kim, S., Jin, J., Kunapuli, S.P. J. Biol. Chem. (2002)
- A single amino acid substitution flanking the fourth calcium binding domain of alpha IIb prevents maturation of the alpha IIb beta 3 integrin complex. Wilcox, D.A., Wautier, J.L., Pidard, D., Newman, P.J. J. Biol. Chem. (1994)
- Independent modulation of von Willebrand factor and fibrinogen binding to the platelet membrane glycoprotein IIb/IIIa complex as demonstrated by monoclonal antibody. Lombardo, V.T., Hodson, E., Roberts, J.R., Kunicki, T.J., Zimmerman, T.S., Ruggeri, Z.M. J. Clin. Invest. (1985)
- A peptide corresponding to GPIIb alpha 300-312, a presumptive fibrinogen gamma-chain binding site on the platelet integrin GPIIb/IIIa, inhibits the adhesion of platelets to at least four adhesive ligands. Taylor, D.B., Gartner, T.K. J. Biol. Chem. (1992)
- A novel homozygous mutation (1619delC) in GPIIb gene associated with Glanzmann thrombasthenia, the decay of GPIIb-mRNA and the synthesis of a truncated GPIIb unable to form complex with GPIIIa. Losonczy, G., Rosenberg, N., Kiss, C., Kappelmayer, J., Vereb, G., Kerényi, A., Balogh, I., Muszbek, L. Thromb. Haemost. (2005)
- Molecular cloning and chemical synthesis of a region of platelet glycoprotein IIb involved in adhesive function. Loftus, J.C., Plow, E.F., Frelinger, A.L., D'Souza, S.E., Dixon, D., Lacy, J., Sorge, J., Ginsberg, M.H. Proc. Natl. Acad. Sci. U.S.A. (1987)
- Extracellular signal-regulated kinase induces the megakaryocyte GPIIb/CD41 gene through MafB/Kreisler. Sevinsky, J.R., Whalen, A.M., Ahn, N.G. Mol. Cell. Biol. (2004)
- Glycoprotein IIb/IIIa inhibition attenuates platelet-activating factor-induced platelet activation by reducing protein kinase C activity. Hu, H., Zhang, W., Li, N. J. Thromb. Haemost. (2003)
- Megakaryocytic differentiation of HIMeg-1 cells induced by interferon gamma and tumour necrosis factor alpha but not by thrombopoietin. Li, J., Franco, R.S., Wang, Y., Pan, H.Q., Eaton, D., Cheng, T., Kaushansky, K., Dai, W. Cytokine (1998)
- Thrombopoietin-induced expression of the glycoprotein IIb gene involves the transcription factor PU.1/Spi-1 in UT7-Mpl cells. Doubeikovski, A., Uzan, G., Doubeikovski, Z., Prandini, M.H., Porteu, F., Gisselbrecht, S., Dusanter-Fourt, I. J. Biol. Chem. (1997)
- Beta2-integrins and acquired glycoprotein IIb/IIIa (GPIIb/IIIa) receptors cooperate in NF-kappaB activation of human neutrophils. Salanova, B., Choi, M., Rolle, S., Wellner, M., Luft, F.C., Kettritz, R. J. Biol. Chem. (2007)
- Calcium-and integrin-binding protein regulates focal adhesion kinase activity during platelet spreading on immobilized fibrinogen. Naik, M.U., Naik, U.P. Blood (2003)
- Epitope mapping by cDNA expression of a monoclonal antibody which inhibits the binding of von Willebrand factor to platelet glycoprotein IIb/IIIa. Piétu, G., Ribba, A.S., Chérel, G., Meyer, D. Biochem. J. (1992)
- Study of platelet adhesion in patients with uncomplicated hypertension. Andrioli, G., Ortolani, R., Fontana, L., Gaino, S., Bellavite, P., Lechi, C., Minuz, P., Manzato, F., Tridente, G., Lechi, A. J. Hypertens. (1996)