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Gene Review

PAPOLB  -  poly(A) polymerase beta (testis specific)

Homo sapiens

Synonyms: PAP-beta, PAPT, Poly(A) polymerase beta, Polynucleotide adenylyltransferase beta, TPAP, ...
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High impact information on PAPOLB

  • (E)-beta-Trialkylstannyl-alpha,beta-unsaturated ketones are readily available from secondary propargylic alcohols via a two-step sequence involving highly regio- and stereoselective Pd(0)-catalyzed hydrostannation followed by mild oxidation (TPAP) [1].
  • The transcription level of Papt in testis of a 2 weeks old mouse was much lower than that of the general poly(A) polymerase gene, Pap. However, the transcription ratio of Papt to Pap was reversed in testis of a 4 weeks old mouse [2].
  • These results suggest that Papt is involved in polyadenylation of transcripts expressed during spermatogenesis [2].
  • Transient expression analysis showed that GFP-Papt fusion protein is present both in the nucleus and cytoplasm of HeLa cells [2].
  • The about 100 residues at the C-terminal region of a nuclear poly(A) polymerase, PAP II, were missing in both PAPT proteins [3].

Biological context of PAPOLB


Analytical, diagnostic and therapeutic context of PAPOLB

  • A hydrophobic polymeric tip of atomic force microscopy has been fabricated by two-photon adsorbed photopolymerization methods (TPAP) [4].


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