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Gene Review

ANXA4  -  annexin A4

Homo sapiens

Synonyms: 35-beta calcimedin, ANX4, Annexin A4, Annexin IV, Annexin-4, ...
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Disease relevance of ANXA4


High impact information on ANXA4

  • In contrast, the expression of annexin II (also called calpactin I) and annexin IV (also called endonexin I) remained relatively unchanged in growing and quiescent HFF cells [6].
  • In addition to the PP4 cDNA we identified 9 other recombinants encoding a protein with considerable similarity (74%) TO PP4, which was termed PP4-X [7].
  • Our work provides mechanistic insight into how annexin A4 may regulate plasma membrane protein function [8].
  • Annexin A4 is a member of this family that is believed to be involved in exocytosis and regulation of epithelial Cl- secretion [8].
  • Dot-blot assay showed that annexin IV interacts with GP-2 in the presence of calcium and that it recognizes the terminal sialic acid residues linked through alpha2-3 linkages to the carbohydrate of GP-2 [9].

Chemical compound and disease context of ANXA4


Biological context of ANXA4


Anatomical context of ANXA4


Associations of ANXA4 with chemical compounds


Regulatory relationships of ANXA4


Other interactions of ANXA4


Analytical, diagnostic and therapeutic context of ANXA4


  1. Annexin proteins PP4 and PP4-X. Comparative characterization of biological activities of placental and recombinant proteins. Römisch, J., Grote, M., Weithmann, K.U., Heimburger, N., Amann, E. Biochem. J. (1990) [Pubmed]
  2. Increased expression and altered location of annexin IV in renal clear cell carcinoma: a possible role in tumour dissemination. Zimmermann, U., Balabanov, S., Giebel, J., Teller, S., Junker, H., Schmoll, D., Protzel, C., Scharf, C., Kleist, B., Walther, R. Cancer Lett. (2004) [Pubmed]
  3. Expression of carbohydrate-binding protein p33/41 in human tumor cell lines. Satoh, A., Takayama, E., Kojima, K., Ogawa, H., Yamori, T., Sato, S., Kawaguchi, T., Tsuruo, T., Katsura, Y., Kina, T., Matsumoto, I. J. Biochem. (1996) [Pubmed]
  4. Characterization of human p33/41 (annexin IV), a Ca2+ dependent carbohydrate-binding protein with monoclonal anti-annexin IV antibodies, AS11 and AS17. Satoh, A., Takayama, E., Kojima, K., Ogawa, H., Katsura, Y., Kina, T., Matsumoto, I. Biol. Pharm. Bull. (1997) [Pubmed]
  5. Prevalence of Chlamydia trachomatis infection in a population of asymptomatic women in a screening program for cervical cancer. Meijer, C.J., Calame, J.J., de Windt, E.J., Risse, E.K., Bleker, O.P., Kenemans, P., Quint, W.G., Meddens, M.J. Eur. J. Clin. Microbiol. Infect. Dis. (1989) [Pubmed]
  6. Expression of annexins as a function of cellular growth state. Schlaepfer, D.D., Haigler, H.T. J. Cell Biol. (1990) [Pubmed]
  7. Characterization of cDNA encoding human placental anticoagulant protein (PP4): homology with the lipocortin family. Grundmann, U., Abel, K.J., Bohn, H., Löbermann, H., Lottspeich, F., Küpper, H. Proc. Natl. Acad. Sci. U.S.A. (1988) [Pubmed]
  8. Annexin A4 self-association modulates general membrane protein mobility in living cells. Piljic, A., Schultz, C. Mol. Biol. Cell (2006) [Pubmed]
  9. A potential endogenous ligand of annexin IV in the exocrine pancreas. Carbohydrate structure of GP-2, a glycosylphosphatidylinositol-anchored glycoprotein of zymogen granule membranes. Tsujii-Hayashi, Y., Kitahara, M., Yamagaki, T., Kojima-Aikawa, K., Matsumoto, I. J. Biol. Chem. (2002) [Pubmed]
  10. Ethanol-induced augmentation of annexin IV expression in rat C6 glioma and human A549 adenocarcinoma cells. Sohma, H., Ohkawa, H., Hashimoto, E., Sakai, R., Saito, T. Alcohol. Clin. Exp. Res. (2002) [Pubmed]
  11. Modulation of paclitaxel resistance by annexin IV in human cancer cell lines. Han, E.K., Tahir, S.K., Cherian, S.P., Collins, N., Ng, S.C. Br. J. Cancer (2000) [Pubmed]
  12. Chromosomal mapping of the human annexin IV (ANX4) gene. Tait, J.F., Smith, C., Frankenberry, D.A., Miao, C.H., Adler, D.A., Disteche, C.M. Genomics (1992) [Pubmed]
  13. Evidence of two forms of poly(A) polymerase in germinated wheat embryos and their regulation by a novel protein kinase. Sharma, N., Dey, M., Satpathy, M., Sachar, R.C. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  14. The Fas-induced apoptosis analyzed by high throughput proteome analysis. Gerner, C., Frohwein, U., Gotzmann, J., Bayer, E., Gelbmann, D., Bursch, W., Schulte-Hermann, R. J. Biol. Chem. (2000) [Pubmed]
  15. Calcium-induced translocation of annexins to subcellular organelles of human neutrophils. Sjölin, C., Stendahl, O., Dahlgren, C. Biochem. J. (1994) [Pubmed]
  16. Placental anticoagulant proteins: isolation and comparative characterization four members of the lipocortin family. Tait, J.F., Sakata, M., McMullen, B.A., Miao, C.H., Funakoshi, T., Hendrickson, L.E., Fujikawa, K. Biochemistry (1988) [Pubmed]
  17. Crystallization and preliminary X-ray crystallographic studies of human placental annexin IV. Freemont, P.S., Driessen, H.P., Verbi, W., Crumpton, M.J. J. Mol. Biol. (1990) [Pubmed]
  18. Augmentation of ethanol-induced cell damage and activation of nuclear factor-kappa B by annexin IV in cultured cells. Sohma, H., Ohkawa, H., Sakai, R., Hashimoto, E., Ukai, W., Saito, T. Alcohol. Clin. Exp. Res. (2003) [Pubmed]
  19. Annexins II, IV, V and VI relocate in response to rises in intracellular calcium in human foreskin fibroblasts. Barwise, J.L., Walker, J.H. J. Cell. Sci. (1996) [Pubmed]
  20. Calcium-dependent binding of the plasma protein apolipoprotein A-I to two members of the annexin family. Brownawell, A.M., Creutz, C.E. Biochemistry (1996) [Pubmed]
  21. Identification of PSME3 as a Novel Serum Tumor Marker for Colorectal Cancer by Combining Two-dimensional Polyacrylamide Gel Electrophoresis with a Strictly Mass Spectrometry-based Approach for Data Analysis. Roessler, M., Rollinger, W., Mantovani-Endl, L., Hagmann, M.L., Palme, S., Berndt, P., Engel, A.M., Pfeffer, M., Karl, J., Bodenm??ller, H., R??schoff, J., Henkel, T., Rohr, G., Rossol, S., R??sch, W., Langen, H., Zolg, W., Tacke, M. Mol. Cell Proteomics (2006) [Pubmed]
  22. A rise in nuclear calcium translocates annexins IV and V to the nuclear envelope. Raynal, P., Kuijpers, G., Rojas, E., Pollard, H.B. FEBS Lett. (1996) [Pubmed]
  23. Changes in expression and subcellular localization of annexin IV in rabbit kidney proximal tubule cells during primary culture. Massey-Harroche, D., Traverso, V., Mayran, N., Francou, V., Vandewalle, A., Maroux, S. J. Cell. Physiol. (1995) [Pubmed]
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