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Gene Review:

TLR4 - toll-like receptor 4

Macaca mulatta

Imaeda, H. et al., Bosinger, S.E. et al.

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High impact information on TLR4

We demonstrate that viral challenge induced a widespread suppression of genes regulating innate immunity, including the LPS receptors, CD14 and TLR4 [1].
The expression of TLR4 and IRAK-1 in the epithelial cells was also examined by immunohistochemistry [2].
TLR4 and IRAK-1 were expressed at the apical membrane of the epithelial cells in the ileum of both control and FITC-LPS injected animals [2].

Biological context of TLR4

Expression of TLR4 and IRAK-1 in the epithelial cells suggests that epithelial cells may react to LPS and produce chemoattractant mediator to induce the neutrophil chemotaxis [2].

References

Gene expression profiling of host response in models of acute HIV infection. Bosinger, S.E., Hosiawa, K.A., Cameron, M.J., Persad, D., Ran, L., Xu, L., Boulassel, M.R., Parenteau, M., Fournier, J., Rud, E.W., Kelvin, D.J. J. Immunol. (2004) [Pubmed]
In vivo response of neutrophils and epithelial cells to lipopolysaccharide injected into the monkey ileum. Imaeda, H., Yamamoto, H., Takaki, A., Fujimiya, M. Histochem. Cell Biol. (2002) [Pubmed]

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