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Gene Review

Tlr4  -  toll-like receptor 4

Rattus norvegicus

Synonyms: Toll-like receptor 4, Toll4
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Disease relevance of Tlr4


High impact information on Tlr4


Biological context of Tlr4


Anatomical context of Tlr4


Associations of Tlr4 with chemical compounds


Regulatory relationships of Tlr4


Other interactions of Tlr4


Analytical, diagnostic and therapeutic context of Tlr4

  • By contrast, while shock/resuscitation alone had no effect on TLR4 mRNA levels, it markedly altered the response to LPS [3].
  • Considered in aggregate, these data suggest that levels of tlr4 expression are controlled both transcriptionally as well as posttranscriptionally through altered mRNA stability and that antecedent shock/resuscitation, a form of global ischemia/reperfusion, might influence regulation of this gene [3].
  • Immunohistochemistry (IHC) was used to detect and localize TLR4 in rat pancreas, and real-time reverse transcription-polymerase chain reaction (RT-PCR) was used to quantitatively determine the expression of TLR4 mRNA in CIP [5].
  • Immunostaining and immunoblotting were performed to detect the presence of CD-14, TLR-2, and TLR-4 [15].
  • Real-time polymerase chain reaction was used to analyze the presence and quantity of mRNA for CD-14, TLR-2, and TLR-4 [15].


  1. Differential expression of the CD14/TLR4 complex and inflammatory signaling molecules following i.c.v. administration of LPS. Xia, Y., Yamagata, K., Krukoff, T.L. Brain Res. (2006) [Pubmed]
  2. Chlamydophila pneumoniae induces expression of toll-like receptor 4 and release of TNF-alpha and MIP-2 via an NF-kappaB pathway in rat type II pneumocytes. Wissel, H., Schulz, C., Koehne, P., Richter, E., Maass, M., Rüdiger, M. Respir. Res. (2005) [Pubmed]
  3. Regulation of Toll-like receptor 4 expression in the lung following hemorrhagic shock and lipopolysaccharide. Fan, J., Kapus, A., Marsden, P.A., Li, Y.H., Oreopoulos, G., Marshall, J.C., Frantz, S., Kelly, R.A., Medzhitov, R., Rotstein, O.D. J. Immunol. (2002) [Pubmed]
  4. Lipopolysaccharide improves cardiomyocyte survival and function after serum deprivation. Chao, W., Shen, Y., Zhu, X., Zhao, H., Novikov, M., Schmidt, U., Rosenzweig, A. J. Biol. Chem. (2005) [Pubmed]
  5. Toll-like receptor 4 detected in exocrine pancreas and the change of expression in cerulein-induced pancreatitis. Li, Y., Zhou, Z.G., Xia, Q.J., Zhang, J., Li, H.G., Cao, G.Q., Wang, R., Lu, Y.L., Hu, T.Z. Pancreas (2005) [Pubmed]
  6. Oxidative stress generated by hemorrhagic shock recruits Toll-like receptor 4 to the plasma membrane in macrophages. Powers, K.A., Szászi, K., Khadaroo, R.G., Tawadros, P.S., Marshall, J.C., Kapus, A., Rotstein, O.D. J. Exp. Med. (2006) [Pubmed]
  7. Activation of innate immunity in the CNS triggers neurodegeneration through a Toll-like receptor 4-dependent pathway. Lehnardt, S., Massillon, L., Follett, P., Jensen, F.E., Ratan, R., Rosenberg, P.A., Volpe, J.J., Vartanian, T. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  8. Ca2+- and Protein Kinase C-dependent Signaling Pathway for Nuclear Factor-{kappa}B Activation, Inducible Nitric-oxide Synthase Expression, and Tumor Necrosis Factor-{alpha} Production in Lipopolysaccharide-stimulated Rat Peritoneal Macrophages. Zhou, X., Yang, W., Li, J. J. Biol. Chem. (2006) [Pubmed]
  9. Cytokine Production in Lipopolysaccharide-exposed Rat Lung Pericytes. Edelman, D.A., Jiang, Y., Tyburski, J.G., Wilson, R.F., Steffes, C.P. The Journal of trauma (2007) [Pubmed]
  10. Expression of toll-like receptor 4 and MD-2 gene and protein in Kupffer cells after ischemia-reperfusion in rat liver graft. Peng, Y., Gong, J.P., Liu, C.A., Li, X.H., Gan, L., Li, S.B. World J. Gastroenterol. (2004) [Pubmed]
  11. Angiotensin II upregulates toll-like receptor 4 on mesangial cells. Wolf, G., Bohlender, J., Bondeva, T., Roger, T., Thaiss, F., Wenzel, U.O. J. Am. Soc. Nephrol. (2006) [Pubmed]
  12. Cytokine responses to fungal pathogens in Kupffer Cells are Toll-like receptor 4 independent and mediated by tyrosine kinases. Overland, G., Stuestøl, J.F., Dahle, M.K., Myhre, A.E., Netea, M.G., Verweij, P., Yndestad, A., Aukrust, P., Kullberg, B.J., Warris, A., Wang, J.E., Aasen, A.O. Scand. J. Immunol. (2005) [Pubmed]
  13. Role of TLR-2 in the activation of nuclear factor kappaB by oxidative stress in cardiac myocytes. Frantz, S., Kelly, R.A., Bourcier, T. J. Biol. Chem. (2001) [Pubmed]
  14. Peptidoglycan of Staphylococcus aureus causes inflammation and organ injury in the rat. Wang, J.E., Dahle, M.K., Yndestad, A., Bauer, I., McDonald, M.C., Aukrust, P., Foster, S.J., Bauer, M., Aasen, A.O., Thiemermann, C. Crit. Care Med. (2004) [Pubmed]
  15. Toll-like receptor-4 message is up-regulated in lipopolysaccharide-exposed rat lung pericytes. Edelman, D.A., Jiang, Y., Tyburski, J., Wilson, R.F., Steffes, C. J. Surg. Res. (2006) [Pubmed]
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