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Gene Review

TLR4  -  toll-like receptor 4

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Disease relevance of TLR4


High impact information on TLR4


Biological context of TLR4


Anatomical context of TLR4


Associations of TLR4 with chemical compounds

  • Mammalian cells respond to bacterial lipopolysaccharide (LPS) through a cognate receptor: Toll-like receptor 4 (TLR4) [9].

Analytical, diagnostic and therapeutic context of TLR4

  • The effect was also abrogated in either C3H/HeJ mouse-derived CD19(+) cell culture or the anti-TLR4 antibody-added culture [10].


  1. Mastitis increases mammary mRNA abundance of beta-defensin 5, toll-like-receptor 2 (TLR2), and TLR4 but not TLR9 in cattle. Goldammer, T., Zerbe, H., Molenaar, A., Schuberth, H.J., Brunner, R.M., Kata, S.R., Seyfert, H.M. Clin. Diagn. Lab. Immunol. (2004) [Pubmed]
  2. Expression and function of Toll-like receptor 4 in the endometrial cells of the uterus. Herath, S., Fischer, D.P., Werling, D., Williams, E.J., Lilly, S.T., Dobson, H., Bryant, C.E., Sheldon, I.M. Endocrinology (2006) [Pubmed]
  3. Toll-like receptor 4-dependent activation of dendritic cells by a retrovirus. Burzyn, D., Rassa, J.C., Kim, D., Nepomnaschy, I., Ross, S.R., Piazzon, I. J. Virol. (2004) [Pubmed]
  4. Characterization of ovine hepatic gene expression profiles in response to Escherichia coli lipopolysaccharide using a bovine cDNA microarray. Cao, H., Kabaroff, L.C., You, Q., Rodriguez, A., Boermans, H.J., Karrow, N.A. BMC Vet. Res. (2006) [Pubmed]
  5. Suppression of NF-kappaB-mediated beta-defensin gene expression in the mammalian airway by the Bordetella type III secretion system. Legarda, D., Klein-Patel, M.E., Yim, S., Yuk, M.H., Diamond, G. Cell. Microbiol. (2005) [Pubmed]
  6. Haplotype variation in bovine Toll-like receptor 4 and computational prediction of a positively selected ligand-binding domain. White, S.N., Taylor, K.H., Abbey, C.A., Gill, C.A., Womack, J.E. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  7. Lactoferrin activates macrophages via TLR4-dependent and -independent signaling pathways. Curran, C.S., Demick, K.P., Mansfield, J.M. Cell. Immunol. (2006) [Pubmed]
  8. Evidence for dissociation of TLR mRNA expression and TLR agonist-mediated functions in bovine macrophages. Franchini, M., Schweizer, M., Mätzener, P., Magkouras, I., Sauter, K.S., Mirkovitch, J., Peterhans, E., Jungi, T.W. Vet. Immunol. Immunopathol. (2006) [Pubmed]
  9. Absence of TRAM restricts Toll-like receptor 4 signaling in vascular endothelial cells to the MyD88 pathway. Harari, O.A., Alcaide, P., Ahl, D., Luscinskas, F.W., Liao, J.K. Circ. Res. (2006) [Pubmed]
  10. Bovine beta-Casein (1-28), a Casein Phosphopeptide, Enhances Proliferation and IL-6 Expression of Mouse CD19(+) Cells via Toll-like Receptor 4. Tobita, K., Kawahara, T., Otani, H. J. Agric. Food Chem. (2006) [Pubmed]
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