The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

TLR4  -  toll-like receptor 4

Gallus gallus

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of TLR4

  • The effects of two genomic regions on chromosomes 7 and 17 harboring two genes, NRAMP1 (SLC11A1) and TLR4, known to be involved in the level of chicken infection 3 d after inoculation by Salmonella were thus tested on a total of 331 hens orally inoculated at the peak of lay with 10(9) bacteria [1].

High impact information on TLR4

  • Single nucleotide polymorphisms (SNP) within the SLC11A1 and TLR4 gene were tested on those animals as well as on a second batch of 279 hens whose resistance was assessed in the same conditions [1].
  • The results showed that Sephadex-elicited, adherence purified K macrophages expressed more inducible TLR4 and CD14 receptors (P<0.05) at 6 and 12h post-LPS stimulation than GB2 macrophages as measured by flow cytometry [2].
  • Our results demonstrate that PI-PLC plays a critical role, most likely through activation of PKC pathway, in TLR4 mediated immune responses of avian macrophage cells to LPS [3].


  1. Effect of two candidate genes on the Salmonella carrier state in fowl. Beaumont, C., Protais, J., Pitel, F., Leveque, G., Malo, D., Lantier, F., Plisson-Petit, F., Colin, P., Protais, M., Le Roy, P., Elsen, J.M., Milan, D., Lantier, I., Neau, A., Salvat, G., Vignal, A. Poult. Sci. (2003) [Pubmed]
  2. Involvement of lipopolysaccharide related receptors and nuclear factor kappa B in differential expression of inducible nitric oxide synthase in chicken macrophages from different genetic backgrounds. Dil, N., Qureshi, M.A. Vet. Immunol. Immunopathol. (2002) [Pubmed]
  3. Involvement of phosphatidylinositol-phospholipase C in immune response to Salmonella lipopolysacharide in chicken macrophage cells (HD11). He, H., Genovese, K.J., Nisbet, D.J., Kogut, M.H. Int. Immunopharmacol. (2006) [Pubmed]
WikiGenes - Universities