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TLR4  -  toll-like receptor 4

Gallus gallus

 
 
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Disease relevance of TLR4

  • The effects of two genomic regions on chromosomes 7 and 17 harboring two genes, NRAMP1 (SLC11A1) and TLR4, known to be involved in the level of chicken infection 3 d after inoculation by Salmonella were thus tested on a total of 331 hens orally inoculated at the peak of lay with 10(9) bacteria [1].
 

High impact information on TLR4

  • Single nucleotide polymorphisms (SNP) within the SLC11A1 and TLR4 gene were tested on those animals as well as on a second batch of 279 hens whose resistance was assessed in the same conditions [1].
  • The results showed that Sephadex-elicited, adherence purified K macrophages expressed more inducible TLR4 and CD14 receptors (P<0.05) at 6 and 12h post-LPS stimulation than GB2 macrophages as measured by flow cytometry [2].
  • Our results demonstrate that PI-PLC plays a critical role, most likely through activation of PKC pathway, in TLR4 mediated immune responses of avian macrophage cells to LPS [3].

References

  1. Effect of two candidate genes on the Salmonella carrier state in fowl. Beaumont, C., Protais, J., Pitel, F., Leveque, G., Malo, D., Lantier, F., Plisson-Petit, F., Colin, P., Protais, M., Le Roy, P., Elsen, J.M., Milan, D., Lantier, I., Neau, A., Salvat, G., Vignal, A. Poult. Sci. (2003) [Pubmed]
  2. Involvement of lipopolysaccharide related receptors and nuclear factor kappa B in differential expression of inducible nitric oxide synthase in chicken macrophages from different genetic backgrounds. Dil, N., Qureshi, M.A. Vet. Immunol. Immunopathol. (2002) [Pubmed]
  3. Involvement of phosphatidylinositol-phospholipase C in immune response to Salmonella lipopolysacharide in chicken macrophage cells (HD11). He, H., Genovese, K.J., Nisbet, D.J., Kogut, M.H. Int. Immunopharmacol. (2006) [Pubmed]
 
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