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Gene Review

runx1  -  runt-related transcription factor 1

Danio rerio

Synonyms: SO:0000704
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High impact information on runx1

  • In irradiated adults, Notch activity induced runx1 gene expression and increased multilineage hematopoietic precursor cells approximately threefold in the marrow [1].
  • Immigrants on the way to the thymus expressed c-myb and ikaros but not rag1; they were probably no longer HSCs, however, because they lacked scl and runx1 expression, unlike immigrants to the kidney [2].
  • The earliest expression detected was that of runx3 in the pharyngeal endoderm, then runx2a and b in mesenchymal condensations, and later runx1 in the epithelium [3].
  • This work has laid the foundation for an ethylnitrosourea (ENU) mutagenesis screen based on runx1 whole-mount in situ hybridzation, that aims to identify genes operative in the runx1 pathway [4].

Anatomical context of runx1

  • Conversely, ubiquitous overexpression of runx3 led to an increase in primitive blood cell numbers, together with an increase in runx1-expressing cells in the ventral wall of the dorsal aorta [5].

Other interactions of runx1


  1. Hematopoietic stem cell fate is established by the Notch-Runx pathway. Burns, C.E., Traver, D., Mayhall, E., Shepard, J.L., Zon, L.I. Genes Dev. (2005) [Pubmed]
  2. Tracing Hematopoietic Precursor Migration to Successive Hematopoietic Organs during Zebrafish Development. Murayama, E., Kissa, K., Zapata, A., Mordelet, E., Briolat, V., Lin, H.F., Handin, R.I., Herbomel, P. Immunity (2006) [Pubmed]
  3. A hierarchy of Runx transcription factors modulate the onset of chondrogenesis in craniofacial endochondral bones in zebrafish. Flores, M.V., Lam, E.Y., Crosier, P., Crosier, K. Dev. Dyn. (2006) [Pubmed]
  4. Pathways in blood and vessel development revealed through zebrafish genetics. Crosier, P.S., Kalev-Zylinska, M.L., Hall, C.J., Flores, M.V., Horsfield, J.A., Crosier, K.E. Int. J. Dev. Biol. (2002) [Pubmed]
  5. Runx3 is required for hematopoietic development in zebrafish. Kalev-Zylinska, M.L., Horsfield, J.A., Flores, M.V., Postlethwait, J.H., Chau, J.Y., Cattin, P.M., Vitas, M.R., Crosier, P.S., Crosier, K.E. Dev. Dyn. (2003) [Pubmed]
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